A member of the ras gene superfamily is expressed specifically in T, B and myeloid hemopoietic cells

N. V. Shirsat; R. J. Pignolo; B. L. Kreider; G. Rovera

A member of the ras gene superfamily is expressed specifically in T, B and myeloid hemopoietic cells

N. V. Shirsat, R. J. Pignolo, B. L. Kreider, G. Rovera

Hospital Internal Medicine

Research output: Contribution to journal › Article › peer-review

90 Scopus citations

Abstract

A 1.26 kb murine cDNA having 31% homology with human ras and 55% homology with human rho proteins was isolated using an oligonucleotide probe homologous to catalytic subdomain of a tyrosine kinase subfamily. Northern blot analysis indicates that the expression of the murine gene is restricted to the cells of hemopoietic lineages and the mRNA levels increase with the terminal differentiation of hemopoietic cells into granulocytes.

Original language	English (US)
Pages (from-to)	769-772
Number of pages	4
Journal	Oncogene
Volume	5
Issue number	5
State	Published - Jun 6 1990

ASJC Scopus subject areas

Molecular Biology
Genetics
Cancer Research

Cite this

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title = "A member of the ras gene superfamily is expressed specifically in T, B and myeloid hemopoietic cells",

abstract = "A 1.26 kb murine cDNA having 31% homology with human ras and 55% homology with human rho proteins was isolated using an oligonucleotide probe homologous to catalytic subdomain of a tyrosine kinase subfamily. Northern blot analysis indicates that the expression of the murine gene is restricted to the cells of hemopoietic lineages and the mRNA levels increase with the terminal differentiation of hemopoietic cells into granulocytes.",

author = "Shirsat, {N. V.} and Pignolo, {R. J.} and Kreider, {B. L.} and G. Rovera",

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AU - Shirsat, N. V.

AU - Pignolo, R. J.

AU - Kreider, B. L.

AU - Rovera, G.

PY - 1990/6/6

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N2 - A 1.26 kb murine cDNA having 31% homology with human ras and 55% homology with human rho proteins was isolated using an oligonucleotide probe homologous to catalytic subdomain of a tyrosine kinase subfamily. Northern blot analysis indicates that the expression of the murine gene is restricted to the cells of hemopoietic lineages and the mRNA levels increase with the terminal differentiation of hemopoietic cells into granulocytes.

AB - A 1.26 kb murine cDNA having 31% homology with human ras and 55% homology with human rho proteins was isolated using an oligonucleotide probe homologous to catalytic subdomain of a tyrosine kinase subfamily. Northern blot analysis indicates that the expression of the murine gene is restricted to the cells of hemopoietic lineages and the mRNA levels increase with the terminal differentiation of hemopoietic cells into granulocytes.

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A member of the ras gene superfamily is expressed specifically in T, B and myeloid hemopoietic cells

Abstract

ASJC Scopus subject areas

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