TY - JOUR
T1 - A knowledgebase resource for interleukin-17 family mediated signaling
AU - Sharma, Jyoti
AU - Balakrishnan, Lavanya
AU - Datta, Keshava K.
AU - Sahasrabuddhe, Nandini A.
AU - Khan, Aafaque Ahmad
AU - Sahu, Apeksha
AU - Singhal, Anish
AU - Getnet, Derese
AU - Raju, Rajesh
AU - Chatterjee, Aditi
AU - Gowda, Harsha
AU - Keshava Prasad, T. S.
AU - Shankar, Subramanian
AU - Pandey, Akhilesh
N1 - Funding Information:
We thank the Department of Biotechnology, Government of India for research support to the Institute of Bioinformatics, Bangalore. We thank the Infosys Foundation for research support to the Institute of Bioinformatics. JS is a recipient of Senior Research Fellowship from the Council of Scientific and Industrial Research, Government of India. KKD and AS are recipients of Junior Research Fellowship from the University Grants Commission, Government of India. AAK is a recipient of Senior Research Fellowship from Indian Council of Medical Research, Government of India. HG is a Wellcome Trust/DBT India Alliance Early Career Fellow.
Publisher Copyright:
© 2015, The International CCN Society.
PY - 2015/9/29
Y1 - 2015/9/29
N2 - Interleukin-17 (IL-17) belongs to a relatively new family of cytokines that has garnered attention as the signature cytokine of Th17 cells. This cytokine family consists of 6 ligands, which bind to 5 receptor subtypes and induce downstream signaling. Although the receptors are ubiquitously expressed, cellular responses to ligands vary across tissues. The cytokine family is associated with various autoimmune disorders including rheumatoid arthritis, multiple sclerosis, inflammatory bowel disease, asthma and psoriasis in addition to being implicated in the pathogenesis of cancer. In addition, this family plays a role in host defense against bacterial and fungal infections. The signaling mechanisms of the IL-17 family of proinflammatory cytokines are not well explored. In this study, we present a resource of literature-annotated reactions induced by IL-17. The reactions are catalogued under 5 categories, namely; molecular association, catalysis, transport, activation/inhibition and gene regulation. A total of 93 molecules and 122 reactions have been annotated. The IL-17 pathway is freely available through NetPath, a resource of signal transduction pathways previously developed by our group.
AB - Interleukin-17 (IL-17) belongs to a relatively new family of cytokines that has garnered attention as the signature cytokine of Th17 cells. This cytokine family consists of 6 ligands, which bind to 5 receptor subtypes and induce downstream signaling. Although the receptors are ubiquitously expressed, cellular responses to ligands vary across tissues. The cytokine family is associated with various autoimmune disorders including rheumatoid arthritis, multiple sclerosis, inflammatory bowel disease, asthma and psoriasis in addition to being implicated in the pathogenesis of cancer. In addition, this family plays a role in host defense against bacterial and fungal infections. The signaling mechanisms of the IL-17 family of proinflammatory cytokines are not well explored. In this study, we present a resource of literature-annotated reactions induced by IL-17. The reactions are catalogued under 5 categories, namely; molecular association, catalysis, transport, activation/inhibition and gene regulation. A total of 93 molecules and 122 reactions have been annotated. The IL-17 pathway is freely available through NetPath, a resource of signal transduction pathways previously developed by our group.
KW - Activation
KW - Differential expression
KW - Inhibition
KW - NetPath
KW - Post-translational modifications
KW - Protein-protein interaction
KW - Translocation
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U2 - 10.1007/s12079-015-0297-3
DO - 10.1007/s12079-015-0297-3
M3 - Article
AN - SCOPUS:84942372843
SN - 1873-9601
VL - 9
SP - 291
EP - 296
JO - Journal of Cell Communication and Signaling
JF - Journal of Cell Communication and Signaling
IS - 3
ER -