A high-pressure situation

Matthew J. Miller; M. John Hicks; Rod Foroozan; Michael C. Brodsky

doi:10.1016/j.survophthal.2022.08.001

A high-pressure situation

Matthew J. Miller, M. John Hicks, Rod Foroozan, Michael C. Brodsky

Ophthalmology

Research output: Contribution to journal › Article › peer-review

Abstract

An 8-year-old boy presented with acute visual loss in the right eye and nausea, vomiting, and diplopia. Imaging revealed a right orbital apex mass. Biopsy showed Langerhans cell histiocytosis (LCH), and the patient was diagnosed with isolated orbital LCH causing an orbital apex syndrome. A 12-month cytarabine chemotherapy course was begun, during which the patient developed bilateral optic disc edema. He was diagnosed with cytarabine-induced intracranial hypertension, which was successfully treated with acetazolamide. The cytarabine course was completed with complete resolution of the LCH lesion. The ophthalmologic relevance of this rare disorder is discussed.

Original language	English (US)
Pages (from-to)	815-820
Number of pages	6
Journal	Survey of ophthalmology
Volume	68
Issue number	4
DOIs	https://doi.org/10.1016/j.survophthal.2022.08.001
State	Published - Jul 1 2023

Keywords

Cytarabine
Intracranial hypertension
Langerhans cell histiocytosis (LCH)
Orbital apex syndrome

ASJC Scopus subject areas

Ophthalmology

Access to Document

10.1016/j.survophthal.2022.08.001

Cite this

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title = "A high-pressure situation",

abstract = "An 8-year-old boy presented with acute visual loss in the right eye and nausea, vomiting, and diplopia. Imaging revealed a right orbital apex mass. Biopsy showed Langerhans cell histiocytosis (LCH), and the patient was diagnosed with isolated orbital LCH causing an orbital apex syndrome. A 12-month cytarabine chemotherapy course was begun, during which the patient developed bilateral optic disc edema. He was diagnosed with cytarabine-induced intracranial hypertension, which was successfully treated with acetazolamide. The cytarabine course was completed with complete resolution of the LCH lesion. The ophthalmologic relevance of this rare disorder is discussed.",

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AU - Miller, Matthew J.

AU - Hicks, M. John

AU - Foroozan, Rod

AU - Brodsky, Michael C.

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AB - An 8-year-old boy presented with acute visual loss in the right eye and nausea, vomiting, and diplopia. Imaging revealed a right orbital apex mass. Biopsy showed Langerhans cell histiocytosis (LCH), and the patient was diagnosed with isolated orbital LCH causing an orbital apex syndrome. A 12-month cytarabine chemotherapy course was begun, during which the patient developed bilateral optic disc edema. He was diagnosed with cytarabine-induced intracranial hypertension, which was successfully treated with acetazolamide. The cytarabine course was completed with complete resolution of the LCH lesion. The ophthalmologic relevance of this rare disorder is discussed.

KW - Cytarabine

KW - Intracranial hypertension

KW - Langerhans cell histiocytosis (LCH)

KW - Orbital apex syndrome

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A high-pressure situation

Abstract

Keywords

ASJC Scopus subject areas

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