A Handheld, Colorimetric Optoelectronic Dynamics Analyzer for Measuring Total Ammonia of Biological Samples

Nai Yuan Liu; Pinar Cay-Durgun; Tianmiao Lai; Mark Sprowls; Leslie Thomas; Mary Laura Lind; Erica Forzani

doi:10.1109/JTEHM.2018.2840678

A Handheld, Colorimetric Optoelectronic Dynamics Analyzer for Measuring Total Ammonia of Biological Samples

Nai Yuan Liu, Pinar Cay-Durgun, Tianmiao Lai, Mark Sprowls, Leslie Thomas, Mary Laura Lind, Erica Forzani

Nephrology

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

This paper introduces a wireless, solid-state, portable, and automated device capable of measuring the total ammonia [ammonia (NH₃) and ammonium (NH₄ ⁺)] levels of fluids, including biological samples. This device reliably measures the total ammonia of biological samples (e.g., urine) faster than the current ammonia quantification techniques. Medical professionals typically estimate NH4⁺ levels using error-prone indirect measurement techniques (i.e., urine anion gap), which are time-consuming and are seldom suitable for periodic measurements. Several instantaneous measurements of total ammonia levels in a patient urine could be utilized as an early warning for both acid-base and/or potassium disturbances. Given the device's operation mechanism, it is able to quantify the total ammonia concentration within a biological sample in only 5 s and can simultaneously transmit data to other devices via Bluetooth. The analytical operation demonstrated high sensitivity, high specificity, fast reversibility, rapid response time, and has enabled the accurate determination of total ammonia concentration in urine samples produced by subjects who had consumed diets of variable protein compositions.

Original language	English (US)
Article number	8404101
Journal	IEEE Journal of Translational Engineering in Health and Medicine
Volume	6
DOIs	https://doi.org/10.1109/JTEHM.2018.2840678
State	Published - Jul 4 2018

Keywords

Biosensors
chemical sensors
clinical diagnosis
medical diagnosis
optoelectronic devices

ASJC Scopus subject areas

Biomedical Engineering

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10.1109/JTEHM.2018.2840678

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title = "A Handheld, Colorimetric Optoelectronic Dynamics Analyzer for Measuring Total Ammonia of Biological Samples",

abstract = "This paper introduces a wireless, solid-state, portable, and automated device capable of measuring the total ammonia [ammonia (NH3) and ammonium (NH4 +)] levels of fluids, including biological samples. This device reliably measures the total ammonia of biological samples (e.g., urine) faster than the current ammonia quantification techniques. Medical professionals typically estimate NH4+ levels using error-prone indirect measurement techniques (i.e., urine anion gap), which are time-consuming and are seldom suitable for periodic measurements. Several instantaneous measurements of total ammonia levels in a patient urine could be utilized as an early warning for both acid-base and/or potassium disturbances. Given the device's operation mechanism, it is able to quantify the total ammonia concentration within a biological sample in only 5 s and can simultaneously transmit data to other devices via Bluetooth. The analytical operation demonstrated high sensitivity, high specificity, fast reversibility, rapid response time, and has enabled the accurate determination of total ammonia concentration in urine samples produced by subjects who had consumed diets of variable protein compositions.",

keywords = "Biosensors, chemical sensors, clinical diagnosis, medical diagnosis, optoelectronic devices",

author = "Liu, {Nai Yuan} and Pinar Cay-Durgun and Tianmiao Lai and Mark Sprowls and Leslie Thomas and Lind, {Mary Laura} and Erica Forzani",

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AU - Lai, Tianmiao

AU - Sprowls, Mark

AU - Thomas, Leslie

AU - Lind, Mary Laura

AU - Forzani, Erica

PY - 2018/7/4

Y1 - 2018/7/4

N2 - This paper introduces a wireless, solid-state, portable, and automated device capable of measuring the total ammonia [ammonia (NH3) and ammonium (NH4 +)] levels of fluids, including biological samples. This device reliably measures the total ammonia of biological samples (e.g., urine) faster than the current ammonia quantification techniques. Medical professionals typically estimate NH4+ levels using error-prone indirect measurement techniques (i.e., urine anion gap), which are time-consuming and are seldom suitable for periodic measurements. Several instantaneous measurements of total ammonia levels in a patient urine could be utilized as an early warning for both acid-base and/or potassium disturbances. Given the device's operation mechanism, it is able to quantify the total ammonia concentration within a biological sample in only 5 s and can simultaneously transmit data to other devices via Bluetooth. The analytical operation demonstrated high sensitivity, high specificity, fast reversibility, rapid response time, and has enabled the accurate determination of total ammonia concentration in urine samples produced by subjects who had consumed diets of variable protein compositions.

AB - This paper introduces a wireless, solid-state, portable, and automated device capable of measuring the total ammonia [ammonia (NH3) and ammonium (NH4 +)] levels of fluids, including biological samples. This device reliably measures the total ammonia of biological samples (e.g., urine) faster than the current ammonia quantification techniques. Medical professionals typically estimate NH4+ levels using error-prone indirect measurement techniques (i.e., urine anion gap), which are time-consuming and are seldom suitable for periodic measurements. Several instantaneous measurements of total ammonia levels in a patient urine could be utilized as an early warning for both acid-base and/or potassium disturbances. Given the device's operation mechanism, it is able to quantify the total ammonia concentration within a biological sample in only 5 s and can simultaneously transmit data to other devices via Bluetooth. The analytical operation demonstrated high sensitivity, high specificity, fast reversibility, rapid response time, and has enabled the accurate determination of total ammonia concentration in urine samples produced by subjects who had consumed diets of variable protein compositions.

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A Handheld, Colorimetric Optoelectronic Dynamics Analyzer for Measuring Total Ammonia of Biological Samples

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Keywords

ASJC Scopus subject areas

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