A genome wide linkage search for breast cancer susceptibility genes

Paula Smith, Lesley McGuffog, Douglas F. Easton, Graham J. Mann, Gulietta M. Pupo, Beth Newman, Georgia Chenevix-Trench, Csilla Szabo, Melissa Southey, Hélène Renard, Fabrice Odefrey, Henry Lynch, Dominique Stoppa-Lyonnet, Fergus Couch, John L. Hopper, Graham G. Giles, Margaret R.E. McCredie, Saundra Buys, Irene Andrulis, Ruby SenieDavid E. Goldgar, Rogier Oldenburg, Karin Kroeze-Jansema, Jaennelle Kraan, Hanne Meijers-Heijboer, Jan G.M. Klijn, Christi Van Asperen, Inge Van Leeuwen, Hans F.A. Vasen, Cees J. Cornelisse, Peter Devilee, Linda Baskcomb, Sheila Seal, Rita Barfoot, Jon Mangion, Anita Hall, Sarah Edkins, Elizabeth Rapley, Richard Wooster, Jenny Chang-Claude, Diana Eccles, D. Gareth Evans, P. Andrew Futreal, Katherine L. Nathanson, Barbara L. Weber, Nazneen Rahman, Michael R. Stratton

Research output: Contribution to journalArticlepeer-review

96 Scopus citations


Mutations in known breast cancer susceptibility genes account for a minority of the familial aggregation of the disease. To search for further breast cancer susceptibility genes, we performed a combined analysis of four genome-wide linkage screens, which included a total of 149 multiple case breast cancer families. All families included at least three cases of breast cancer diagnosed below age 60 years, at least one of whom had been tested and found not to carry a BRCA1 or BRCA2 mutation. Evidence for linkage was assessed using parametric linkage analysis, assuming both a dominant and a recessive mode of inheritance, and using nonparametric methods. The highest LOD score obtained in any analysis of the combined data was 1.80 under the dominant model, in a region on chromosome 4 close to marker D4S392. Three further LOD scores over 1 were identified in the parametric analyses and two in the nonparametric analyses. A maximum LOD score of 2.40 was found on chromosome arm 2p in families with four or more cases of breast cancer diagnosed below age 50 years. The number of linkage peaks did not differ from the number expected by chance. These results suggest regions that may harbor novel breast cancer susceptibility genes. They also indicate that no single gene is likely to account for a large fraction of the familial aggregation of breast cancer that is not due to mutations in BRCA1 or BRCA2.

Original languageEnglish (US)
Pages (from-to)646-655
Number of pages10
JournalGenes Chromosomes and Cancer
Issue number7
StatePublished - Jul 2006

ASJC Scopus subject areas

  • Genetics
  • Cancer Research


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