A genome-wide association study of antidepressant-induced mania

Clement C. Zai; Alessio Squassina; Arun K. Tiwari; Claudia Pisanu; Marco Pinna; Federica Pinna; Anna Meloni; Pasquale Paribello; Bernardo Carpiniello; Leonardo Tondo; Mark A. Frye; Joanna M. Biernacka; Brandon J. Coombes; James L. Kennedy; Mirko Manchia

doi:10.1016/j.pnpbp.2023.110800

A genome-wide association study of antidepressant-induced mania

Clement C. Zai, Alessio Squassina, Arun K. Tiwari, Claudia Pisanu, Marco Pinna, Federica Pinna, Anna Meloni, Pasquale Paribello, Bernardo Carpiniello, Leonardo Tondo, Mark A. Frye, Joanna M. Biernacka, Brandon J. Coombes, James L. Kennedy, Mirko Manchia

Research output: Contribution to journal › Article › peer-review

Abstract

Antidepressant-induced mania (AIM) is a side effect of antidepressant treatment that is characterized by mania or hypomania after the start of medication. It is likely polygenic, but its genetic component remains largely unexplored. We aim to conduct the first genome-wide association study of AIM in 814 bipolar disorder patients of European ancestry. We report no significant findings from our single-marker or gene-based analyses. Our polygenic risk score analyses also did not yield significant results with bipolar disorder, antidepressant response, or lithium response. Our suggestive findings on the hypothalamic-pituitary-adrenal axis and the opioid system in AIM require independent replications.

Original language	English (US)
Article number	110800
Journal	Progress in Neuro-Psychopharmacology and Biological Psychiatry
Volume	127
DOIs	https://doi.org/10.1016/j.pnpbp.2023.110800
State	Published - Dec 20 2023

Keywords

Antidepressant-induced mania
Bipolar disorder
Depression
Genome-wide association study
Pharmacogenetics

ASJC Scopus subject areas

Pharmacology
Biological Psychiatry

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10.1016/j.pnpbp.2023.110800

Cite this

Zai, C. C., Squassina, A., Tiwari, A. K., Pisanu, C., Pinna, M., Pinna, F., Meloni, A., Paribello, P., Carpiniello, B., Tondo, L., Frye, M. A., Biernacka, J. M., Coombes, B. J., Kennedy, J. L., & Manchia, M. (2023). A genome-wide association study of antidepressant-induced mania. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 127, Article 110800. https://doi.org/10.1016/j.pnpbp.2023.110800

Zai, CC, Squassina, A, Tiwari, AK, Pisanu, C, Pinna, M, Pinna, F, Meloni, A, Paribello, P, Carpiniello, B, Tondo, L, Frye, MA , Biernacka, JM , Coombes, BJ, Kennedy, JL & Manchia, M 2023, 'A genome-wide association study of antidepressant-induced mania', Progress in Neuro-Psychopharmacology and Biological Psychiatry, vol. 127, 110800. https://doi.org/10.1016/j.pnpbp.2023.110800

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abstract = "Antidepressant-induced mania (AIM) is a side effect of antidepressant treatment that is characterized by mania or hypomania after the start of medication. It is likely polygenic, but its genetic component remains largely unexplored. We aim to conduct the first genome-wide association study of AIM in 814 bipolar disorder patients of European ancestry. We report no significant findings from our single-marker or gene-based analyses. Our polygenic risk score analyses also did not yield significant results with bipolar disorder, antidepressant response, or lithium response. Our suggestive findings on the hypothalamic-pituitary-adrenal axis and the opioid system in AIM require independent replications.",

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AU - Pinna, Marco

AU - Pinna, Federica

AU - Meloni, Anna

AU - Paribello, Pasquale

AU - Carpiniello, Bernardo

AU - Tondo, Leonardo

AU - Frye, Mark A.

AU - Biernacka, Joanna M.

AU - Coombes, Brandon J.

AU - Kennedy, James L.

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A genome-wide association study of antidepressant-induced mania

Abstract

Keywords

ASJC Scopus subject areas

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