@inproceedings{fd9e4226692048c69620656a08b2e6d2,
title = "A comprehensive (biological and computational) investigation on the role of microRNA::mRNA regulations performed in chronic obstructive pulmonary disease and lung cancer",
abstract = "Chronic obstructive pulmonary disease (COPD) and lung cancer (LC) are two serious diseases that present a major health problem worldwide. However, genetic contribution to both diseases remains unclear, including various regulation mechanisms at genetic level resulting in the progression from COPD to LC. In this paper, we describe our comprehensive methodologies, which seamlessly integrate both biological (conducted in 'wet labs') and computational (based on domain ontologies and semantic technologies) approaches, to investigate the important role of microRNA::mRNA regulations performed in COPD and LC. We discovered two genes, RGS6 and PARK2, that are strongly associated with the risk of developing either COPD or LC or both; additionally, we also identified two sets of microRNAs that are computationally predicted to regulate RGS6 and PARK2, respectively. These microRNAs can be further biologically verified in the future and serve as novel biomarkers in COPD and/or LC.",
keywords = "Bio-ontology, COPD, Chronic obstructive pulmonary disease, Lung cancer, MicroRNA, Semantic search, Target gene",
author = "Jingshan Huang and Dejing Dou and Jun She and Limper, {Andrew H.} and Yanan Yang and Ping Yang",
note = "Funding Information: Research reported in this paper was partially supported by the the National Institutes of Health (NIH), under the Award Numbers UOICA180982, ROICA80127, ROICA84354, and ROIHLl07612. The views contained in this paper are solely the responsibility of the authors and do not represent the official views, either expressed or implied, of the NIH or the U.S. Government Publisher Copyright: {\textcopyright} 2016 IEEE.; 2016 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2016 ; Conference date: 15-12-2016 Through 18-12-2016",
year = "2017",
month = jan,
day = "17",
doi = "10.1109/BIBM.2016.7822669",
language = "English (US)",
series = "Proceedings - 2016 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2016",
publisher = "Institute of Electrical and Electronics Engineers Inc.",
pages = "1062--1067",
editor = "Kevin Burrage and Qian Zhu and Yunlong Liu and Tianhai Tian and Yadong Wang and Hu, {Xiaohua Tony} and Qinghua Jiang and Jiangning Song and Shinichi Morishita and Kevin Burrage and Guohua Wang",
booktitle = "Proceedings - 2016 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2016",
}