TY - JOUR
T1 - A Clinicopathologic Comparison Between Early-Onset and Late-Onset Small Bowel Adenocarcinoma
T2 - A Multicenter International Study
AU - Small Bowel Carcinoma Consortium
AU - Arpa, Giovanni
AU - Vanoli, Alessandro
AU - Antoci, Francesca
AU - Lenti, Marco Vincenzo
AU - Di Sabatino, Antonio
AU - Guerini, Camilla
AU - Grillo, Federica
AU - Bianchi, Paola Ilaria
AU - Aronico, Nicola
AU - Libera, Laura
AU - Furlan, Daniela
AU - Travaglino, Erica
AU - Nesi, Gabriella
AU - Sampietro, Gianluca
AU - Ardizzone, Sandro
AU - Fociani, Paolo
AU - Fiocca, Roberto
AU - Latella, Giovanni
AU - Sessa, Fausto
AU - D’Errico, Antonietta
AU - Malvi, Deborah
AU - Mescoli, Claudia
AU - Rugge, Massimo
AU - Ferrero, Stefano
AU - Poggioli, Gilberto
AU - Rizzello, Fernando
AU - Macciomei, Maria C.
AU - Santini, Donatella
AU - Volta, Umberto
AU - De Giorgio, Roberto
AU - Caio, Giacomo
AU - Calabrò, Antonio
AU - Ciacci, Carolina
AU - D’Armiento, Maria
AU - Rizzo, Aroldo
AU - Solina, Gaspare
AU - Tonelli, Francesco
AU - Villanacci, Vincenzo
AU - Cannizzaro, Renato
AU - Canzonieri, Vincenzo
AU - Florena, Ada M.
AU - Biancone, Livia
AU - Monteleone, Giovanni
AU - Caronna, Roberto
AU - Ciardi, Antonio
AU - Elli, Luca
AU - Caprioli, Flavio
AU - Vecchi, Maurizio
AU - D’Incà, Renata
AU - Graham, Rondell P.
N1 - Publisher Copyright:
© 2023 by The American College of Gastroenterology.
PY - 2024/3/1
Y1 - 2024/3/1
N2 - INTRODUCTION: Early-onset small bowel adenocarcinoma (EO-SBA) is a rare and poorly characterized entity. METHODS: This retrospective study conducted on an international multicenter cohort of 208 patients with SBA aimed at comparing clinicopathologic features of EO-SBA (age younger than 50 years at SBA diagnosis) and late-onset SBA (age 50 years or older at SBA diagnosis). RESULTS: The presence of predisposing pathologic conditions was significantly more common in the EO-SBA group compared with that in the late-onset SBA group (P 5 0.003, Fisher exact test; relative risk: 1.50, 95% confidence interval: 1.20–1.86). This difference is mainly due to the significantly higher prevalence of celiac disease among patients with EO-SBA. DISCUSSION: EO-SBA is strongly associated with predisposing conditions, particularly with celiac disease, highlighting the importance of routine screening for celiac disease in patients with EO-SBA.
AB - INTRODUCTION: Early-onset small bowel adenocarcinoma (EO-SBA) is a rare and poorly characterized entity. METHODS: This retrospective study conducted on an international multicenter cohort of 208 patients with SBA aimed at comparing clinicopathologic features of EO-SBA (age younger than 50 years at SBA diagnosis) and late-onset SBA (age 50 years or older at SBA diagnosis). RESULTS: The presence of predisposing pathologic conditions was significantly more common in the EO-SBA group compared with that in the late-onset SBA group (P 5 0.003, Fisher exact test; relative risk: 1.50, 95% confidence interval: 1.20–1.86). This difference is mainly due to the significantly higher prevalence of celiac disease among patients with EO-SBA. DISCUSSION: EO-SBA is strongly associated with predisposing conditions, particularly with celiac disease, highlighting the importance of routine screening for celiac disease in patients with EO-SBA.
KW - celiac disease
KW - Crohn’s disease
KW - immune-mediated disorders
KW - mismatch repair
KW - small bowel cancer
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U2 - 10.14309/ajg.0000000000002585
DO - 10.14309/ajg.0000000000002585
M3 - Article
C2 - 37966091
AN - SCOPUS:85187156762
SN - 0002-9270
VL - 119
SP - 576
EP - 579
JO - American Journal of Gastroenterology
JF - American Journal of Gastroenterology
IS - 3
ER -