A clinical and histopathologic focus on barrett esophagus and barrett-related dysplasia

Lysandra Voltaggio, Elizabeth A. Montgomery, Dora Lam-Himlin

Research output: Contribution to journalReview articlepeer-review

29 Scopus citations


Context.-Barrett esophagus is a metaplastic, premalignant lesion associated with approximately 0.5% annual incidence of progression to esophageal adenocarcinoma. Diagnosis and screening of Barrett esophagus and Barrett-related dysplasia relies on histologic evaluation of endoscopic mucosal biopsies, a process that is burdened with interobserver variability. Objectives.-To review the histologic features and classification of Barrett esophagus and Barrett-related dysplasia, to discuss the underlying difficulties in diagnosis and pitfalls, and to provide a brief review of new developments related to therapeutic modalities for patients diagnosed with dysplasia. Data Sources.-Sources include a review of relevant literature indexed in PubMed (US National Library of Medicine). Conclusions.-In spite of interobserver variability, histologic assessment of dysplasia is currently the accepted method of surveillance, and subsequent patient management is dictated by this evaluation. Although not universal, endoscopic therapy is increasingly important in replacing esophagectomy for patients with high-grade dysplasia or early carcinoma.

Original languageEnglish (US)
Pages (from-to)1249-1260
Number of pages12
JournalArchives of Pathology and Laboratory Medicine
Issue number10
StatePublished - Oct 2011

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology


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