@article{b55cd3ed88fb4f20b5ddc5adf2fec574,
title = "A chronic wound model to investigate skin cellular senescence",
abstract = "Wound healing is an essential physiological process for restoring normal skin structure and function post-injury. The role of cellular senescence, an essentially irreversible cell cycle state in response to damaging stimuli, has emerged as a critical mechanism in wound remodeling. Transiently-induced senescence during tissue remodeling has been shown to be beneficial in the acute wound healing phase. In contrast, persistent senescence, as observed in chronic wounds, contributes to delayed closure.",
keywords = "cellular senescence, chronic wound, re-epithelization, skin, wound healing",
author = "Wyles, {Saranya P.} and Parisa Dashti and Tamar Pirtskhalava and Burak Tekin and Christina Inman and Gomez, {Lilian Sales} and Lagnado, {Anthony B.} and Larissa Prata and Diana Jurk and Passos, {Jo{\~a}o F.} and Tamar Tchkonia and Kirkland, {James L.}",
note = "Funding Information: This study was supported by funding from the Mayo Clinic Robert and Arlene Kogod Center on Aging, Mayo Clinic Department of Dermatology, National Institutes of Health grants R37AG13925 and P01AG62413, the Connor Fund, Robert J. and Theresa W. Ryan, and the Noaber Foundation. We also acknowledge R01 AG068182, R01 AG066679, UG3 CA268103 and the Ted Nash Long Life Foundation Funding Information: This study was supported by funding from the Mayo Clinic Robert and Arlene Kogod Center on Aging, Mayo Clinic Department of Dermatology, National Institutes of Health grants R37AG13925 and P01AG62413, the Connor Fund, Robert J. and Theresa W. Ryan, and the Noaber Foundation. We also acknowledge R01 AG068182, R01 AG066679, UG3 CA268103 and the Ted Nash Long Life Foundation. Publisher Copyright: {\textcopyright} 2023 Wyles et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited",
year = "2023",
doi = "10.18632/aging.204667",
language = "English (US)",
volume = "15",
pages = "2852--2862",
journal = "Aging",
issn = "1945-4589",
publisher = "US Administration on Aging",
number = "8",
}