A challenging case of stage IV EGFR-mutant lung cancer with histologic transformation and multiple resistance mechanisms

Joel Rivera-Concepcion; Ying Chun Lo; Dipesh Uprety; Alex A. Adjei; Vinicius Ernani; Konstantinos Leventakos

doi:10.1016/j.cpccr.2024.100284

A challenging case of stage IV EGFR-mutant lung cancer with histologic transformation and multiple resistance mechanisms

Joel Rivera-Concepcion, Ying Chun Lo, Dipesh Uprety, Alex A. Adjei, Vinicius Ernani, Konstantinos Leventakos

Research output: Contribution to journal › Article › peer-review

Abstract

This clinical case presents a patient with NSCLC who experienced on-target resistant mutations and tumor cell transformation from adenocarcinoma to large cell neuroendocrine and small cell carcinoma. Our patient was successfully treated with a combination of targeted therapy, immunotherapy and chemotherapy based on genetic and histologic changes that occurred in a period of five years.

Original language	English (US)
Article number	100284
Journal	Current Problems in Cancer: Case Reports
Volume	13
DOIs	https://doi.org/10.1016/j.cpccr.2024.100284
State	Published - Mar 2024

Keywords

Acquired resistance
EGFR mutation
Histologic transformation
NSCLC
Neuroendocrine cancer

ASJC Scopus subject areas

Oncology

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10.1016/j.cpccr.2024.100284

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title = "A challenging case of stage IV EGFR-mutant lung cancer with histologic transformation and multiple resistance mechanisms",

abstract = "This clinical case presents a patient with NSCLC who experienced on-target resistant mutations and tumor cell transformation from adenocarcinoma to large cell neuroendocrine and small cell carcinoma. Our patient was successfully treated with a combination of targeted therapy, immunotherapy and chemotherapy based on genetic and histologic changes that occurred in a period of five years.",

keywords = "Acquired resistance, EGFR mutation, Histologic transformation, NSCLC, Neuroendocrine cancer",

author = "Joel Rivera-Concepcion and Lo, {Ying Chun} and Dipesh Uprety and Adjei, {Alex A.} and Vinicius Ernani and Konstantinos Leventakos",

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AU - Lo, Ying Chun

AU - Uprety, Dipesh

AU - Adjei, Alex A.

AU - Ernani, Vinicius

AU - Leventakos, Konstantinos

PY - 2024/3

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N2 - This clinical case presents a patient with NSCLC who experienced on-target resistant mutations and tumor cell transformation from adenocarcinoma to large cell neuroendocrine and small cell carcinoma. Our patient was successfully treated with a combination of targeted therapy, immunotherapy and chemotherapy based on genetic and histologic changes that occurred in a period of five years.

AB - This clinical case presents a patient with NSCLC who experienced on-target resistant mutations and tumor cell transformation from adenocarcinoma to large cell neuroendocrine and small cell carcinoma. Our patient was successfully treated with a combination of targeted therapy, immunotherapy and chemotherapy based on genetic and histologic changes that occurred in a period of five years.

KW - Acquired resistance

KW - EGFR mutation

KW - Histologic transformation

KW - NSCLC

KW - Neuroendocrine cancer

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A challenging case of stage IV EGFR-mutant lung cancer with histologic transformation and multiple resistance mechanisms

Abstract

Keywords

ASJC Scopus subject areas

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