A case of bilateral renal arterial thrombosis associated with cryocrystalglobulinaemia

Nelson Leung, Francis K. Buadi, Kevin W. Song, Alexander B. Magil, Lynn D. Cornell

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Cryocrystalglobulinaemia is an extremely rare complication of monoclonal gammopathy. Its presentation has features of both type I and II cryoglobulinaemia. Although peripheral and digital ischaemia is common, visceral ischaemia is rare. When it does occur, it is usually associated with multiple myeloma and has an extremely poor prognosis. We present a case of bilateral renal artery thrombosis associated with cryocrystalglobulinaemia in a patient without myeloma. More unusual, the cryocrystal protein in this case was associated with fibrinogen, which may have led to increased propensity towards thrombosis. Although the patient was unable to recover his kidney function, he remained alive on dialysis 2 years after the incident. The patient did not have any further ischaemic event despite no definitive therapy. This case represents an unusual presentation for this rare disease.

Original languageEnglish (US)
Pages (from-to)74-77
Number of pages4
JournalNDT Plus
Issue number1
StatePublished - Feb 2010


  • cryocrystalglobulinaemia
  • crystal
  • monoclonal
  • renal artery thrombosis

ASJC Scopus subject areas

  • Nephrology
  • Transplantation


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