TY - JOUR
T1 - A Case-Control Study of Peripartum Cardiomyopathy Using the Rochester Epidemiology Project
AU - Douglass, ERIKA J.
AU - COOPER, LESLIE T.
AU - MORALES-LARA, A. CAROLINA
AU - ADEDINSEWO, DEMILADE A.
AU - ROZEN, TODD D.
AU - BLAUWET, LORI A.
AU - FAIRWEATHER, DELISA
N1 - Funding Information:
This study was made possible using the resources of the Rochester Epidemiology Project, which is supported by the National Institute on Aging of the National Institutes of Health under Award Number R01AG034676. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. This study was supported by grants from the NIH (R01 HL111938, R21 ES024414, R21 AI145356, R21 AI152318, R21 AI154927) and the American Heart Association (16GRNT30950007) to D.F. The sponsors were not involved in the study design, collection, analysis and interpretation of data, in writing the manuscript or in the decision to submit the article for publication.
Publisher Copyright:
© 2021 The Authors
PY - 2021/2
Y1 - 2021/2
N2 - Background: The incidence of peripartum cardiomyopathy (PPCM) is known through referral center databases that may be affected by referral, misclassification, and other biases. We sought to determine the community-based incidence and natural history of PPCM using the Rochester Epidemiology Project. Methods and Results: Incident cases of PPCM occurring between January 1, 1970, and December 31, 2014, were identified in Olmsted County, Minnesota. A total of 15 PPCM cases were confirmed yielding an incidence of 20.3 cases per 100,000 live births in Olmsted County, Minnesota. Clinical information, disease characteristics, and outcomes were extracted from medical records in a 27-county region of the Rochester Epidemiology Project including Olmsted County and matched in a 1:2 ratio with pregnant women without PPCM. A total of 48 women were identified with PPCM in the expanded 27-county region. There was 1 death and no transplants over a median of 7.3 years of follow-up. Six of the 23 women with subsequent pregnancies developed recurrent PPCM, all of whom recovered. Migraine and anxiety were identified as novel possible risk factors for PPCM. Conclusions: The population-based incidence of PPCM was 20.3 cases per 100,000 live births in Olmsted County, Minnesota. Cardiovascular outcomes were generally excellent in this community cohort.
AB - Background: The incidence of peripartum cardiomyopathy (PPCM) is known through referral center databases that may be affected by referral, misclassification, and other biases. We sought to determine the community-based incidence and natural history of PPCM using the Rochester Epidemiology Project. Methods and Results: Incident cases of PPCM occurring between January 1, 1970, and December 31, 2014, were identified in Olmsted County, Minnesota. A total of 15 PPCM cases were confirmed yielding an incidence of 20.3 cases per 100,000 live births in Olmsted County, Minnesota. Clinical information, disease characteristics, and outcomes were extracted from medical records in a 27-county region of the Rochester Epidemiology Project including Olmsted County and matched in a 1:2 ratio with pregnant women without PPCM. A total of 48 women were identified with PPCM in the expanded 27-county region. There was 1 death and no transplants over a median of 7.3 years of follow-up. Six of the 23 women with subsequent pregnancies developed recurrent PPCM, all of whom recovered. Migraine and anxiety were identified as novel possible risk factors for PPCM. Conclusions: The population-based incidence of PPCM was 20.3 cases per 100,000 live births in Olmsted County, Minnesota. Cardiovascular outcomes were generally excellent in this community cohort.
KW - Heart failure
KW - incidence
KW - migraine
KW - pregnancy
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U2 - 10.1016/j.cardfail.2020.12.021
DO - 10.1016/j.cardfail.2020.12.021
M3 - Article
C2 - 33388468
AN - SCOPUS:85100503962
SN - 1071-9164
VL - 27
SP - 132
EP - 142
JO - Journal of Cardiac Failure
JF - Journal of Cardiac Failure
IS - 2
ER -