A c-Myc-SIRT1 feedback loop regulates cell growth and transformation

Jian Yuan, Katherine Minter-Dykhouse, Zhenkun Lou

Research output: Contribution to journalArticlepeer-review

161 Scopus citations


The protein deacetylase SIRT1 has been implicated in a variety of cellular functions, including development, cellular stress responses, and metabolism. Increasing evidence suggests that similar to its counterpart, Sir2, in yeast, Caenorhabditis elegans, and Drosophila melanogaster, SIRT1 may function to regulate life span in mammals. However, SIRT1's role in cancer is unclear. During our investigation of SIRT1, we found that c-Myc binds to the SIRT1 promoter and induces SIRT1 expression. However, SIRT1 interacts with and deacetylates c-Myc, resulting in decreased c-Myc stability. As a consequence, c-Myc's transformational capability is compromised in the presence of SIRT1. Overall, our experiments identify a c-Myc-SIRT1 feedback loop in the regulation of c-Myc activity and cellular transformation, supporting/suggesting a role of SIRT1 in tumor suppression.

Original languageEnglish (US)
Pages (from-to)203-211
Number of pages9
JournalJournal of Cell Biology
Issue number2
StatePublished - Apr 20 2009

ASJC Scopus subject areas

  • Cell Biology


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