Abstract
Circular polarization of luminescence spectra of human plasminogen and of its derivatives were measured in solutions of ligand-free proteins and with saturating amounts of 6-aminohexanoic acid. Spectroscopic changes induced by the ligand reveal similar perturbations of the binding sites in all the protein derivatives. It is concluded that the gross conformational change induced by 6-aminohexanoic acid binding to the native plasminogen involves changes of sterical relations of entire protein domains.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 971-975 |
| Number of pages | 5 |
| Journal | Biochemical and Biophysical Research Communications |
| Volume | 91 |
| Issue number | 3 |
| DOIs | |
| State | Published - Dec 14 1979 |
ASJC Scopus subject areas
- Biophysics
- Biochemistry
- Molecular Biology
- Cell Biology