1.5T MRI-guided trans-perineal laser ablation of locally recurrent prostate adenocarcinoma

E. Frederick McPhail; Lance A. Mynderse; Matthew R. Callstrom; Krzysztof R. Gorny; Roger J. McNichols; Thomas D. Atwell; Matthew T. Gettman; Kimberly K. Amrami; Akira Kawashima; David A. Woodrum

doi:10.1117/12.844992

1.5T MRI-guided trans-perineal laser ablation of locally recurrent prostate adenocarcinoma

E. Frederick McPhail, Lance A. Mynderse, Matthew R. Callstrom, Krzysztof R. Gorny, Roger J. McNichols, Thomas D. Atwell, Matthew T. Gettman, Kimberly K. Amrami, Akira Kawashima, David A. Woodrum

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Introduction: Biochemical recurrence of prostate cancer after definitive therapy with radical prostatectomy (RP) is known to occur between 25-30%. We present the first known case of 1.5T MRI guided ablation using laser interstitial thermal therapy (LITT) for locally recurrent prostate cancer following RP. Methods: The patient elected to undergo MRI-guided LITT of the biopsy proven cancer recurrence using an FDAapproved MRI compatible, 980nm, 15-watt laser system with MR thermometry. Under T2-weighted MR(1.5T Siemens) imaging, guidance and targeting of the lesions with trans-perineal placement of laser applicators. Multiple cycles of laser energy were used to ablate the tumor. A MRI-compatible urethral cooling catheter was placed to prevent urethral thermal damage. Results: Intra-procedural temperature mapping allowed continuous monitoring of the ablation zone and permitted ablation control until tumor coverage was achieved. Additionally, the protective cooling effects of the urethral cooling catheter could also be seen with the temperature mapping. Post-ablation gadolinium and T2 weighted MR imaging demonstrated an ablation defect encompassing the recurrent tumor with no residual hyper-enhancing nodules. Three month follow-up shows no residual or recurrent tumor seen on MR imaging. Conclusion: This represents the first known, successful, MRI-guided, LITT procedures at 1.5T for locally recurrent prostate adenocarcinoma following RP.

Original language	English (US)
Title of host publication	Photonic Therapeutics and Diagnostics VI
DOIs	https://doi.org/10.1117/12.844992
State	Published - Dec 1 2010
Event	Photonic Therapeutics and Diagnostics VI - San Francisco, CA, United States Duration: Jan 23 2010 → Jan 25 2010

Publication series

Name	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	7548
ISSN (Print)	1605-7422

Other

Other	Photonic Therapeutics and Diagnostics VI
Country/Territory	United States
City	San Francisco, CA
Period	1/23/10 → 1/25/10

Keywords

MR-intervention
MRI
laser ablation
prostate cancer
prostate cancer recurrence

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Biomaterials
Atomic and Molecular Physics, and Optics
Radiology Nuclear Medicine and imaging

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10.1117/12.844992

Cite this

McPhail, E. F., Mynderse, L. A., Callstrom, M. R., Gorny, K. R., McNichols, R. J., Atwell, T. D., Gettman, M. T., Amrami, K. K., Kawashima, A., & Woodrum, D. A. (2010). 1.5T MRI-guided trans-perineal laser ablation of locally recurrent prostate adenocarcinoma. In Photonic Therapeutics and Diagnostics VI Article 754816 (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 7548). https://doi.org/10.1117/12.844992

1.5T MRI-guided trans-perineal laser ablation of locally recurrent prostate adenocarcinoma. / McPhail, E. Frederick; Mynderse, Lance A.; Callstrom, Matthew R. et al.
Photonic Therapeutics and Diagnostics VI. 2010. 754816 (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 7548).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

McPhail, EF, Mynderse, LA, Callstrom, MR, Gorny, KR, McNichols, RJ, Atwell, TD, Gettman, MT, Amrami, KK, Kawashima, A & Woodrum, DA 2010, 1.5T MRI-guided trans-perineal laser ablation of locally recurrent prostate adenocarcinoma. in Photonic Therapeutics and Diagnostics VI., 754816, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 7548, Photonic Therapeutics and Diagnostics VI, San Francisco, CA, United States, 1/23/10. https://doi.org/10.1117/12.844992

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title = "1.5T MRI-guided trans-perineal laser ablation of locally recurrent prostate adenocarcinoma",

abstract = "Introduction: Biochemical recurrence of prostate cancer after definitive therapy with radical prostatectomy (RP) is known to occur between 25-30%. We present the first known case of 1.5T MRI guided ablation using laser interstitial thermal therapy (LITT) for locally recurrent prostate cancer following RP. Methods: The patient elected to undergo MRI-guided LITT of the biopsy proven cancer recurrence using an FDAapproved MRI compatible, 980nm, 15-watt laser system with MR thermometry. Under T2-weighted MR(1.5T Siemens) imaging, guidance and targeting of the lesions with trans-perineal placement of laser applicators. Multiple cycles of laser energy were used to ablate the tumor. A MRI-compatible urethral cooling catheter was placed to prevent urethral thermal damage. Results: Intra-procedural temperature mapping allowed continuous monitoring of the ablation zone and permitted ablation control until tumor coverage was achieved. Additionally, the protective cooling effects of the urethral cooling catheter could also be seen with the temperature mapping. Post-ablation gadolinium and T2 weighted MR imaging demonstrated an ablation defect encompassing the recurrent tumor with no residual hyper-enhancing nodules. Three month follow-up shows no residual or recurrent tumor seen on MR imaging. Conclusion: This represents the first known, successful, MRI-guided, LITT procedures at 1.5T for locally recurrent prostate adenocarcinoma following RP.",

keywords = "MR-intervention, MRI, laser ablation, prostate cancer, prostate cancer recurrence",

author = "McPhail, {E. Frederick} and Mynderse, {Lance A.} and Callstrom, {Matthew R.} and Gorny, {Krzysztof R.} and McNichols, {Roger J.} and Atwell, {Thomas D.} and Gettman, {Matthew T.} and Amrami, {Kimberly K.} and Akira Kawashima and Woodrum, {David A.}",

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AU - McPhail, E. Frederick

AU - Mynderse, Lance A.

AU - Callstrom, Matthew R.

AU - Gorny, Krzysztof R.

AU - McNichols, Roger J.

AU - Atwell, Thomas D.

AU - Gettman, Matthew T.

AU - Amrami, Kimberly K.

AU - Kawashima, Akira

AU - Woodrum, David A.

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N2 - Introduction: Biochemical recurrence of prostate cancer after definitive therapy with radical prostatectomy (RP) is known to occur between 25-30%. We present the first known case of 1.5T MRI guided ablation using laser interstitial thermal therapy (LITT) for locally recurrent prostate cancer following RP. Methods: The patient elected to undergo MRI-guided LITT of the biopsy proven cancer recurrence using an FDAapproved MRI compatible, 980nm, 15-watt laser system with MR thermometry. Under T2-weighted MR(1.5T Siemens) imaging, guidance and targeting of the lesions with trans-perineal placement of laser applicators. Multiple cycles of laser energy were used to ablate the tumor. A MRI-compatible urethral cooling catheter was placed to prevent urethral thermal damage. Results: Intra-procedural temperature mapping allowed continuous monitoring of the ablation zone and permitted ablation control until tumor coverage was achieved. Additionally, the protective cooling effects of the urethral cooling catheter could also be seen with the temperature mapping. Post-ablation gadolinium and T2 weighted MR imaging demonstrated an ablation defect encompassing the recurrent tumor with no residual hyper-enhancing nodules. Three month follow-up shows no residual or recurrent tumor seen on MR imaging. Conclusion: This represents the first known, successful, MRI-guided, LITT procedures at 1.5T for locally recurrent prostate adenocarcinoma following RP.

AB - Introduction: Biochemical recurrence of prostate cancer after definitive therapy with radical prostatectomy (RP) is known to occur between 25-30%. We present the first known case of 1.5T MRI guided ablation using laser interstitial thermal therapy (LITT) for locally recurrent prostate cancer following RP. Methods: The patient elected to undergo MRI-guided LITT of the biopsy proven cancer recurrence using an FDAapproved MRI compatible, 980nm, 15-watt laser system with MR thermometry. Under T2-weighted MR(1.5T Siemens) imaging, guidance and targeting of the lesions with trans-perineal placement of laser applicators. Multiple cycles of laser energy were used to ablate the tumor. A MRI-compatible urethral cooling catheter was placed to prevent urethral thermal damage. Results: Intra-procedural temperature mapping allowed continuous monitoring of the ablation zone and permitted ablation control until tumor coverage was achieved. Additionally, the protective cooling effects of the urethral cooling catheter could also be seen with the temperature mapping. Post-ablation gadolinium and T2 weighted MR imaging demonstrated an ablation defect encompassing the recurrent tumor with no residual hyper-enhancing nodules. Three month follow-up shows no residual or recurrent tumor seen on MR imaging. Conclusion: This represents the first known, successful, MRI-guided, LITT procedures at 1.5T for locally recurrent prostate adenocarcinoma following RP.

KW - MR-intervention

KW - MRI

KW - laser ablation

KW - prostate cancer

KW - prostate cancer recurrence

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1.5T MRI-guided trans-perineal laser ablation of locally recurrent prostate adenocarcinoma

Abstract

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