1,25-Dihydroxyvitamin D stimulation test for osteoblast function in normal and osteoporotic postmenopausal women

R. J. Duda; R. Kumar; K. I. Nelson; A. R. Zinsmeister; K. G. Mann; B. L. Riggs

doi:10.1172/JCI112944

1,25-Dihydroxyvitamin D stimulation test for osteoblast function in normal and osteoporotic postmenopausal women

R. J. Duda, R. Kumar, K. I. Nelson, A. R. Zinsmeister, K. G. Mann, B. L. Riggs

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Abstract

The cause of bone loss in postmenopausal osteoporosis - decreased bone formation or increased bone resorption - is controversial. Synthesis of bone-Gla protein (BGP), a specific osteoblast product, is stimulated by 1,25-dihydroxyvitamin D₃ [1,25(OH)₂D] in vitro. Thus, increases in serum BGP levels during 1,25(OH)₂D administration might provide a useful dynamic index of osteoblast function. We compared 14 postmenopausal osteoporotic women with 12 age-matched postmenopausal normal women before and during 6 d of 1,25(OH)₂D administration (2.0 μg/d). Serum BGP levels were similar at baseline and increased during treatment in both groups (P < 0.001). However, trend analysis showed a greater (P < 0.01) increase in the osteoporotic women. These data do not support the hypothesis that defective osteoblast function is the major cause of bone loss in postmenopausal osteoporosis.

Original language	English (US)
Pages (from-to)	1249-1253
Number of pages	5
Journal	Journal of Clinical Investigation
Volume	79
Issue number	4
DOIs	https://doi.org/10.1172/JCI112944
State	Published - 1987

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Medicine(all)

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title = "1,25-Dihydroxyvitamin D stimulation test for osteoblast function in normal and osteoporotic postmenopausal women",

abstract = "The cause of bone loss in postmenopausal osteoporosis - decreased bone formation or increased bone resorption - is controversial. Synthesis of bone-Gla protein (BGP), a specific osteoblast product, is stimulated by 1,25-dihydroxyvitamin D3 [1,25(OH)2D] in vitro. Thus, increases in serum BGP levels during 1,25(OH)2D administration might provide a useful dynamic index of osteoblast function. We compared 14 postmenopausal osteoporotic women with 12 age-matched postmenopausal normal women before and during 6 d of 1,25(OH)2D administration (2.0 μg/d). Serum BGP levels were similar at baseline and increased during treatment in both groups (P < 0.001). However, trend analysis showed a greater (P < 0.01) increase in the osteoporotic women. These data do not support the hypothesis that defective osteoblast function is the major cause of bone loss in postmenopausal osteoporosis.",

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AU - Duda, R. J.

AU - Kumar, R.

AU - Nelson, K. I.

AU - Zinsmeister, A. R.

AU - Mann, K. G.

AU - Riggs, B. L.

PY - 1987

Y1 - 1987

N2 - The cause of bone loss in postmenopausal osteoporosis - decreased bone formation or increased bone resorption - is controversial. Synthesis of bone-Gla protein (BGP), a specific osteoblast product, is stimulated by 1,25-dihydroxyvitamin D3 [1,25(OH)2D] in vitro. Thus, increases in serum BGP levels during 1,25(OH)2D administration might provide a useful dynamic index of osteoblast function. We compared 14 postmenopausal osteoporotic women with 12 age-matched postmenopausal normal women before and during 6 d of 1,25(OH)2D administration (2.0 μg/d). Serum BGP levels were similar at baseline and increased during treatment in both groups (P < 0.001). However, trend analysis showed a greater (P < 0.01) increase in the osteoporotic women. These data do not support the hypothesis that defective osteoblast function is the major cause of bone loss in postmenopausal osteoporosis.

AB - The cause of bone loss in postmenopausal osteoporosis - decreased bone formation or increased bone resorption - is controversial. Synthesis of bone-Gla protein (BGP), a specific osteoblast product, is stimulated by 1,25-dihydroxyvitamin D3 [1,25(OH)2D] in vitro. Thus, increases in serum BGP levels during 1,25(OH)2D administration might provide a useful dynamic index of osteoblast function. We compared 14 postmenopausal osteoporotic women with 12 age-matched postmenopausal normal women before and during 6 d of 1,25(OH)2D administration (2.0 μg/d). Serum BGP levels were similar at baseline and increased during treatment in both groups (P < 0.001). However, trend analysis showed a greater (P < 0.01) increase in the osteoporotic women. These data do not support the hypothesis that defective osteoblast function is the major cause of bone loss in postmenopausal osteoporosis.

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1,25-Dihydroxyvitamin D stimulation test for osteoblast function in normal and osteoporotic postmenopausal women

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