TY - JOUR
T1 - 1,25-Dihydroxyvitamin D-mediated hypercalcemia in a renal transplant recipient
AU - Golconda, Muralikrishna S.
AU - Larson, Tlmothy S.
AU - Külb, Llsa G.
AU - Kumar, Rajiv
N1 - Funding Information:
This study was supported in part by Grants DK 25409 and DK 42971 from the National Institutes of Health, Public Health Service.
PY - 1996
Y1 - 1996
N2 - Hypercalcemia occurs in 10 to 30% of renal transplant recipients and is most often due to persistent hyperparathyroidism. Herein we describe a patient with a history of hyperparathyroidism who sought medical assessment because of recurrence of hypercalcemia 7 years after a successful renal transplantation. The hypercalcemia was associated with a normal serum phosphate level, a low to normal parathyroid hormone level, virtually undetectable levels of parathyroid hormone-related protein, and increased 1,25-dihydroxyvitamin D levels. Further assessment led to the diagnosis of an underlying lymphoma. To our knowledge, this is the first report of 1,25- dihydroxyvitamin D-mediated hypercalcemia in a renal transplant recipient with lymphoma. The possibility of an underlying lymphoproliferative disorder should be considered in the differential diagnosis of hypercalcemia in a renal transplant recipient.
AB - Hypercalcemia occurs in 10 to 30% of renal transplant recipients and is most often due to persistent hyperparathyroidism. Herein we describe a patient with a history of hyperparathyroidism who sought medical assessment because of recurrence of hypercalcemia 7 years after a successful renal transplantation. The hypercalcemia was associated with a normal serum phosphate level, a low to normal parathyroid hormone level, virtually undetectable levels of parathyroid hormone-related protein, and increased 1,25-dihydroxyvitamin D levels. Further assessment led to the diagnosis of an underlying lymphoma. To our knowledge, this is the first report of 1,25- dihydroxyvitamin D-mediated hypercalcemia in a renal transplant recipient with lymphoma. The possibility of an underlying lymphoproliferative disorder should be considered in the differential diagnosis of hypercalcemia in a renal transplant recipient.
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U2 - 10.4065/71.1.32
DO - 10.4065/71.1.32
M3 - Article
C2 - 8538229
AN - SCOPUS:0030033660
SN - 0025-6196
VL - 71
SP - 32
EP - 36
JO - Mayo Clinic proceedings
JF - Mayo Clinic proceedings
IS - 1
ER -