1 kHz vibration stimulates ATDC5 chondrocytes

Heather Argadine, Mark Bolander, James Greenleaf

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations


Low-intensity pulsed ultrasound is a commonly prescribed therapy for delayed unions and nonunions after fractures. Several clinical trials have shown that a 1.5 MHz ultrasound signal at a 200 μs tone burst repeating at 1 kHz shortens the time to normal bone strength by 30%. In vitro studies have shown that pulsed ultrasound increases aggrecan gene expression in chondrocytes. The pulsed 1.5 MHz signal produces radiation force vibration at 1 kHz. It was hypothesized that dynamic radiation force, not ultrasound, is responsible for the biological effect of the signal. Experiments showed that 1 kHz induced chondrogenesis similar to pulsed ultrasound treatment. These results have implications for stimulation of different types of strain-sensitive cells.

Original languageEnglish (US)
Title of host publicationTHERAPEUTIC ULTRASOUND
Subtitle of host publication5th International Symposium on Therapeutic Ultrasound
Number of pages5
StatePublished - May 8 2006
EventTHERAPEUTIC ULTRASOUND: 5th International Symposium on Therapeutic Ultrasound - Boston, MA, United States
Duration: Oct 27 2005Oct 29 2005

Publication series

NameAIP Conference Proceedings
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616


OtherTHERAPEUTIC ULTRASOUND: 5th International Symposium on Therapeutic Ultrasound
Country/TerritoryUnited States
CityBoston, MA


  • 1 kHz
  • ATDC5
  • Chondrocyte
  • Ehondrogenesis
  • Fracture
  • Ultrasound

ASJC Scopus subject areas

  • General Physics and Astronomy


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