1 kHz low power sound stimulates ATDC5 chondrocytes

Heather M. Argadine, Randall R. Kinnick, Mark E. Bolander, James F. Greenleaf

Research output: Chapter in Book/Report/Conference proceedingConference contribution

8 Scopus citations


A current clinical product from Smith and Nephew uses a pulsed 1.5 MHz signal for treating fractures 20 minutes per day. This pulsed 1.5 MHz signal produces radiation force vibration at 1 kHz. It was hypothesized that the radiation force, not the ultrasound, is responsible for the biological effect of the Smith and Nephew system of stimulating chondrocytes. In vitro experiments using the following method indeed showed that treatment with 1 kHz induced chondrogenesis similar to treatment with 1.5 MHz pulsed ultrasound. This study provides the first evidence for 1 kHz activation of chondrocytes and for the potential mechanisms with which this vibration is sensed in the cell.

Original languageEnglish (US)
Title of host publication2005 IEEE Ultrasonics Symposium
Number of pages3
StatePublished - Dec 1 2005
Event2005 IEEE Ultrasonics Symposium - Rotterdam, Netherlands
Duration: Sep 18 2005Sep 21 2005

Publication series

NameProceedings - IEEE Ultrasonics Symposium
ISSN (Print)1051-0117


Other2005 IEEE Ultrasonics Symposium


  • 1 kHz
  • ATDC5
  • Chondrocyte
  • Chondrogenesis

ASJC Scopus subject areas

  • Acoustics and Ultrasonics


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