Transcriptomic Signatures of Influenza Vaccine Responses

PROJECT NARRATIVE Relevance to Public Health: Influenza A/H3N2 virus is one of the more virulent and pathogenic of the influenza viruses that infect, sicken, and kill humans in the United States and worldwide, especially in older individuals. This grant will provide novel information describing how innate and T helper cell immune responses to MF59-adjuvanted influenza vaccine (MF59Flu) and high-dose seasonal influenza vaccine (HDFlu) are generated in a well-characterized cohort of older individuals (65 years of age and older) across sex and vaccine type. Using high-dimensional omics data, this study will identify genetic signatures associated with both innate and adaptive immune response profiles.