Project Details
Description
Project Summary
Our proposal addresses the important issue of defining the clinical consequences of low count Monoclonal B
cell lymphocytosis (LC MBL) and providing insight into why 5-10% of U.S. adults over the age of 40 develop
this condition.
MBL - the precursor state to chronic lymphocytic leukemia (CLL), is one of the most common premalignant
conditions in humans. Individuals with MBL have a circulating clonal B cell population, an absolute B cell count
98%) of
individuals with MBL have LC MBL and never come to clinical attention. The clinical consequences of LC MBL
are largely unknown. Despite the low risk of progression to CLL, individuals with LC MBL are likely to have
other important clinical consequences.
In a preliminary study of 1001 adults age >40, we found that individuals with LC MBL have reduced overall
survival and increased risk of life-threatening infections. This suggests that 5-10% of adults over age 40 have a
largely unstudied, acquired, asymptomatic condition with potentially important clinical implications. Currently
little to no information is known about the risk factors for developing MBL. We are now poised via this
proposal to determine the critical clinical consequences of LC MBL with respect to risk of infection
and non-hematologic malignancy and to identify the risk factors for developing LC MBL. This is
because of our unique opportunity to study MBL using the Mayo Clinic Biobank, the only tissue repository in
the USA we are aware of that stores peripheral blood mononuclear cells in a manner that permits testing for
the presence of LC MBL. This Biobank is linked to the Mayo Clinic Medical record and provides exceptionally
well annotated prospective follow-up to evaluate clinical outcomes. Participants in the Biobank also provided
detailed information on epidemiologic, health and behavioral risk factors at the time of blood collection which
allows evaluation of how these factors relate to MBL risk. In this proposal, we will harness this unique platform
to robustly define the clinical outcomes associated with LC MBL and the risk factors for developing this age
related clinical condition which affects 5-10% of adults over the age of 40.
Status | Finished |
---|---|
Effective start/end date | 9/1/18 → 5/31/23 |
Funding
- National Institute on Aging: $464,153.00
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