Project Details
Description
Since joining the NIDA National Drug Abuse Treatment Clinical Trials Network (CTN) in 2015, the NorthStar
Node has made significant contributions to the objectives and priorities of the CTN. The NorthStar Node and its
investigators have led or co-led five CTN protocols, served as a research site for seven CTN studies, co-
chaired the CTN Steering Committee and the Data Science Work Group, served on the Research
Development Committee, and contributed to several special interest groups. The NorthStar Node's research
portfolio includes traditional randomized controlled trials (CTN-0068), pragmatic comparative effectiveness
research (CTN-0098A and CTN-0099), implementation science (CTN-0074, CTN-0098B, and CTN-0099),
community-based participatory research (CTN-0096), data science (CTN-0076 and CTN-0087), and health
services research (CTN-0070). In this application, the NorthStar Node has seven guiding objectives
(POLARIS): 1) generating evidence that informs Policy and clinical guidelines; 2) evaluating models
addressing co-Occurring SUD and medical and psychiatric conditions; 3) using principals of a Learning health
system to conduct pragmatic trials; 4) using Artificial intelligence and other data sciences approaches to
enhance SUD research and care; 5) Reaching understudied populations to ensure SUD research is relevant to
diverse populations; 6) using Implementation science to test the integration of evidence-based SUD practices
into general medical settings; and 7) testing innovative Strategies for SUD treatment. Potential studies to meet
these objectives include 1) a novel therapeutic intervention for methamphetamine use disorder; 2)
development of machine learning algorithms in the electronic health record to target substance use screening
and enhance substance use disorder diagnoses; 3) precision/personalized medicine studies using population
pharmacokinetics to better define and refine medication dosing strategies that improve treatment outcome; and
4) testing collaborative care models to address co-occurring chronic medical illnesses in specialty addiction
treatment settings. Our expertise spans multi-site clinical trials, implementation science, community-based
participatory research, EHR-based interventions, machine learning and natural language processing, and
health services research. In addition to community partners that include urban and rural integrated health
systems, federally qualified health centers serving underrepresented minorities, specialty addiction treatment
programs, and pediatric and adolescent health clinics, the NorthStar Node brings affiliated research and
dissemination networks into the CTN, including CTSA, SIREN, PCORNet, JCOIN, HOPE, the Network
Coordinating Office of the Addiction Technology Transfer Centers, a learning health system training program
(K12), three NIDA training programs (T32), and fellowship programs in addiction medicine and addiction
psychiatry. The NorthStar Node is well situated to address current and emerging SUD issues and advance
research in the field in order to improve patient outcome and transform health systems.
Status | Finished |
---|---|
Effective start/end date | 9/1/15 → 2/29/24 |
Funding
- National Institute on Drug Abuse: $238,670.00
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