Does retrogenesis explain regional white matter integrity in MCI?

Neuropathologists have observed that the pattern of degenerative brain changes in Alzheimer's disease appears to occur in the reverse order as that of normal brain development, particularly in white matter. Dr. Stricker's study will investigate this pattern of white matter changes at early stages of Alzheimer's disease and aim to help define early patterns of neurodegeneration. By understanding the pattern of neurodegenerative changes, specific brain regions along this pathway can be better targeted for early detection and clinical trials. Determining the role of white matter changes in the development of Alzheimer's disease may aid in earlier detection and alter future treatment efforts.