Zinc increases the excitability of dopaminergic neurons in rat substantia nigra

Jun Mo Chung; Su Youne Chang; Yang In Kim; Hyung Chul Shin

doi:10.1016/S0304-3940(00)01120-4

Zinc increases the excitability of dopaminergic neurons in rat substantia nigra

Jun Mo Chung, Su Youne Chang, Yang In Kim, Hyung Chul Shin

Neurosurgery

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

The effect of zinc ions (Zn²⁺) on the neuronal excitability of substantia nigra (SN) where the zinc level is known higher in Parkinsonian brains than that in normal brains has not yet been elucidated. We, therefore, examined the effect of Zn²⁺ on the intrinsic electrical properties of dopaminergic SN neurons, using a whole-cell recording method. Zn²⁺ hyperpolarized dopaminergic SN neurons at resting state. Also Zn²⁺ shortened the duration of evoked spikes, developed a fast afterhyperpolarization, and increased their firing frequency. Voltage-clamp studies showed that Zn²⁺ decreased 4-aminopyridine-sensitive outward currents, suggesting that a transient A-like potassium channel be one of the major targets Zn²⁺ can modulate in the SN neurons. (C) 2000 Elsevier Science Ireland Ltd.

Original language	English (US)
Pages (from-to)	183-186
Number of pages	4
Journal	Neuroscience Letters
Volume	286
Issue number	3
DOIs	https://doi.org/10.1016/S0304-3940(00)01120-4
State	Published - Jun 9 2000

Keywords

Electrophysiology
Metals
Midbrain
Parkinson's diseases
Whole cell recording

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/S0304-3940(00)01120-4

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title = "Zinc increases the excitability of dopaminergic neurons in rat substantia nigra",

abstract = "The effect of zinc ions (Zn2+) on the neuronal excitability of substantia nigra (SN) where the zinc level is known higher in Parkinsonian brains than that in normal brains has not yet been elucidated. We, therefore, examined the effect of Zn2+ on the intrinsic electrical properties of dopaminergic SN neurons, using a whole-cell recording method. Zn2+ hyperpolarized dopaminergic SN neurons at resting state. Also Zn2+ shortened the duration of evoked spikes, developed a fast afterhyperpolarization, and increased their firing frequency. Voltage-clamp studies showed that Zn2+ decreased 4-aminopyridine-sensitive outward currents, suggesting that a transient A-like potassium channel be one of the major targets Zn2+ can modulate in the SN neurons. (C) 2000 Elsevier Science Ireland Ltd.",

keywords = "Electrophysiology, Metals, Midbrain, Parkinson's diseases, Whole cell recording",

author = "Chung, {Jun Mo} and Chang, {Su Youne} and Kim, {Yang In} and Shin, {Hyung Chul}",

note = "Funding Information: This study was supported in part by a grant from Hallym Academy of Sciences, a grant from Korean Ministry of Science and Technology under the Brain Science Research Program (98-BR-02–02-A-01), the KOSEF grant through the CCSR Research Fund, and Brain Korea 21 Project to J.M.C. S.Y.C. is a Lotte scholarship recipient.",

year = "2000",

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doi = "10.1016/S0304-3940(00)01120-4",

language = "English (US)",

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pages = "183--186",

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T1 - Zinc increases the excitability of dopaminergic neurons in rat substantia nigra

AU - Chung, Jun Mo

AU - Chang, Su Youne

AU - Kim, Yang In

AU - Shin, Hyung Chul

N1 - Funding Information: This study was supported in part by a grant from Hallym Academy of Sciences, a grant from Korean Ministry of Science and Technology under the Brain Science Research Program (98-BR-02–02-A-01), the KOSEF grant through the CCSR Research Fund, and Brain Korea 21 Project to J.M.C. S.Y.C. is a Lotte scholarship recipient.

PY - 2000/6/9

Y1 - 2000/6/9

N2 - The effect of zinc ions (Zn2+) on the neuronal excitability of substantia nigra (SN) where the zinc level is known higher in Parkinsonian brains than that in normal brains has not yet been elucidated. We, therefore, examined the effect of Zn2+ on the intrinsic electrical properties of dopaminergic SN neurons, using a whole-cell recording method. Zn2+ hyperpolarized dopaminergic SN neurons at resting state. Also Zn2+ shortened the duration of evoked spikes, developed a fast afterhyperpolarization, and increased their firing frequency. Voltage-clamp studies showed that Zn2+ decreased 4-aminopyridine-sensitive outward currents, suggesting that a transient A-like potassium channel be one of the major targets Zn2+ can modulate in the SN neurons. (C) 2000 Elsevier Science Ireland Ltd.

AB - The effect of zinc ions (Zn2+) on the neuronal excitability of substantia nigra (SN) where the zinc level is known higher in Parkinsonian brains than that in normal brains has not yet been elucidated. We, therefore, examined the effect of Zn2+ on the intrinsic electrical properties of dopaminergic SN neurons, using a whole-cell recording method. Zn2+ hyperpolarized dopaminergic SN neurons at resting state. Also Zn2+ shortened the duration of evoked spikes, developed a fast afterhyperpolarization, and increased their firing frequency. Voltage-clamp studies showed that Zn2+ decreased 4-aminopyridine-sensitive outward currents, suggesting that a transient A-like potassium channel be one of the major targets Zn2+ can modulate in the SN neurons. (C) 2000 Elsevier Science Ireland Ltd.

KW - Electrophysiology

KW - Metals

KW - Midbrain

KW - Parkinson's diseases

KW - Whole cell recording

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U2 - 10.1016/S0304-3940(00)01120-4

DO - 10.1016/S0304-3940(00)01120-4

M3 - Article

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AN - SCOPUS:0034625732

SN - 0304-3940

VL - 286

SP - 183

EP - 186

JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 3

ER -

Zinc increases the excitability of dopaminergic neurons in rat substantia nigra

Abstract

Keywords

ASJC Scopus subject areas

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