Whole-Genome Sequencing in Healthy People

Noralane M. Lindor, Stephen N. Thibodeau, Wylie Burke

Research output: Contribution to journalReview articlepeer-review

25 Scopus citations


Recent technological advances have radically changed genetic testing from an expensive and burdensome undertaking to a rapid and less costly option for many purposes. The utility of “next-generation” sequencing has been found to establish the diagnosis for hundreds of genetic disorders, to assess pharmacogenomic variants, and to identify treatable targets within malignant neoplasms. The ready availability of genomic information has led to the question of whether there would be clinical benefit of sequencing the genome of individuals who are not seeking a diagnosis, that is, genomic screening in generally healthy people, to provide anticipatory insights for their health care. Little research has been conducted in this area. We examine the considerable unresolved scientific and ethical issues encountered when considering whole-genome sequencing of healthy people.

Original languageEnglish (US)
Pages (from-to)159-172
Number of pages14
JournalMayo Clinic proceedings
Issue number1
StatePublished - Jan 1 2017

ASJC Scopus subject areas

  • General Medicine


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