White matter integrity in dementia with Lewy bodies: A voxel-based analysis of diffusion tensor imaging

Zuzana Nedelska, Christopher G. Schwarz, Bradley F. Boeve, Val J. Lowe, Robert I. Reid, Scott A. Przybelski, Timothy G. Lesnick, Jeffrey L. Gunter, Matthew L. Senjem, Tanis J. Ferman, Glenn E. Smith, Yonas E. Geda, David S. Knopman, Ronald C. Petersen, Clifford R. Jack, Kejal Kantarci

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


Many patients with dementia with Lewy bodies (DLB) have overlapping Alzheimer's disease (AD)-related pathology, which may contribute to white matter (WM) diffusivity alterations on diffusion tensor imaging (DTI). Consecutive patients with DLB (n= 30), age- and sex-matched AD patients (n= 30), and cognitively normal controls (n= 60) were recruited. All subjects underwent DTI, 18F 2-fluoro-deoxy-d-glucose, and 11CPittsburgh compound B positron emission tomography scans. DLB patients had reduced fractionalanisotropy (FA) in the parietooccipital WM but not elsewhere compared with cognitively normal controls, and elevated FA in parahippocampal WM compared with AD patients, which persisted after controlling for β-amyloid load in DLB. The pattern of WM FA alterations on DTI was consistent with the more diffuse posterior parietal and occipital glucose hypometabolism of 2-fluoro-deoxy-d-glucose positron emission tomography in the cortex. DLB is characterized by a loss of parietooccipital WM integrity, independent of concomitant AD-related β-amyloid load. Cortical glucose hypometabolism accompanies WM FA alterations with a concordant pattern of gray and WM involvement in the parietooccipital lobes in DLB.

Original languageEnglish (US)
Pages (from-to)2010-2017
Number of pages8
JournalNeurobiology of aging
Issue number6
StatePublished - Jun 1 2015


  • Amyloid-beta load
  • Cortical hypometabolism
  • Dementia with Lewy bodies
  • Diffusion tensor imaging
  • Voxel-based analysis
  • White matter integrity

ASJC Scopus subject areas

  • Neuroscience(all)
  • Aging
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology


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