What is type 2 diabetes?

Galina Smushkin, Adrian Vella

Research output: Contribution to journalReview articlepeer-review

21 Scopus citations


Type 2 diabetes is a common metabolic disorder characterized by chronic hyperglycaemia. It is associated with a reduced life expectancy owing to a greater risk of heart disease, stroke, peripheral neuropathy, renal disease, blindness and amputation. At present, the best predictors of increased diabetes risk and progression to diabetes are an elevated fasting plasma glucose, an abnormal glucose tolerance test, obesity and evidence of impaired insulin action. However, the mechanisms by which people with impaired fasting glucose and/or abnormal glucose tolerance 'progress' to overt type 2 diabetes are not completely understood. Moreover, type 2 diabetes is defined in a 'negative' sense (hyperglycaemia occurring in the absence of evidence of autoimmune destruction of islet cells). This has two consequences - one is the heterogeneity of the disease, the other is that the disease is identified purely in terms of hyperglycaemia, to a certain extent ignoring the underlying mechanisms that lead to the disease. In this review, we explore some of these mechanisms in an attempt to remind readers that hyperglycaemia is one of many abnormalities in type 2 diabetes.

Original languageEnglish (US)
Pages (from-to)597-601
Number of pages5
Issue number11
StatePublished - Nov 2010


  • incretin hormones
  • insulin action
  • insulin secretion
  • pre-diabetes
  • type 2 diabetes

ASJC Scopus subject areas

  • Medicine(all)


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