What Constitutes an “Adequate” Trial in Migraine Prevention?

Jonathan H. Smith, Todd J. Schwedt

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations


Comprehensively assessing the quality of prior preventive treatment attempts often reveals modifiable variables that may account for treatment failure. Similarly, a comprehensive and systematic approach when planning a preventive medication trial is critical for optimizing the chances of treatment success. In this review, we summarize the key elements to be included when assessing the adequacy of a preventive treatment trial. We have developed and included checklists that can be used by providers to improve their assessments of prior preventive treatment trials and to assist with planning a high-quality treatment trial with a new migraine preventive medication.

Original languageEnglish (US)
Article number52
JournalCurrent pain and headache reports
Issue number11
StatePublished - Nov 22 2015


  • Clinical trial
  • Migraine
  • Outcome
  • Prevention
  • Quality

ASJC Scopus subject areas

  • Clinical Neurology
  • Anesthesiology and Pain Medicine


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