Virtual colonoscopy with magnetic resonance imaging: In vitro evaluation of a new concept

A. W. Schoenenberger, P. Bauerfeind, G. P. Krestin, J. F. Debatin, D. A. Ahlquist, C. D. Johnson

Research output: Contribution to journalArticlepeer-review

54 Scopus citations


Background and Aims: Screening for colonic polyps is desirable. A new concept based on cross-sectional and endoscopic analysis of a magnetic resonance (MR) data set is presented. Methods: Ex vivo autopsy colonic specimens, containing artificially placed polyps, were obtained and filled with a gadolinium-containing solution. Forty-four thin-section MR images were obtained in a 1.5-T MR scanner in 28 seconds. A three-dimensional endoscopic fly-through of these images was rendered. Fly-throughs and two-dimensional cross-sectional images were analyzed by two observers for the presence of polyps. Results: The average sensitivity and specificity for the detection of polyps based on three-dimensional endoscopic MR colon imaging were 87% and 96%, respectively. Analysis of cross-sectional images showed an overall sensitivity and specificity of merely 57% and 84%, respectively. The difference in the interpretation of three-dimensional MR colonoscopy and two- dimensional cross-sections was statistically significant (P < 0.001). With three-dimensional MR colonoscopy, overall sensitivity for detection of polyps measuring ≤5 mm in length and diameter was 70%; for larger polyps, it increased to 95% (P < 0.01). Conclusions: The feasibility of an MR-based endoluminal assessment of the colon is shown. Minimal invasiveness, lack of radiation exposure, and high in vitro diagnostic accuracy warrant further investigation of this novel concept.

Original languageEnglish (US)
Pages (from-to)1863-1870
Number of pages8
Issue number6
StatePublished - 1997

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology


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