Ventricular enlargement and its clinical correlates in the imaging cohort from the adcs mci donepezil/vitamin e study

Liana G. Apostolova, Sona Babakchanian, Kristy S. Hwang, Amity E. Green, Dimitar Zlatev, Yi Yu Chou, Charlie Decarli, Clifford R. Jack, Ronald C. Petersen, Paul S. Aisen, Jeffrey L. Cummings, Arthur W. Toga, Paul M. Thompson

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


We analyzed the baseline and 3-year T1-weighted magnetic resonance imaging data of 110 amnestic mild cognitive impairment (MCI) participants with minimal hippocampal atrophy at baseline from the Alzheimer's Disease Cooperative Study group MCI Donepezil/Vitamin E trial. Forty-six subjects converted to Alzheimer disease (AD) (MCIc), whereas 64 remained stable (MCInc). We used the radial distance technique to examine the differences in lateral ventricle shape and size between MCIc and MCInc and the associations between ventricular enlargement and cognitive decline. MCIc group had significantly larger frontal and right body/occipital horns relative to MCInc at baseline and significantly larger bilateral frontal, body/occipital, and left temporal horns at follow-up. Global cognitive decline measured with AD Assessment scale cognitive subscale and Mini-Mental State Examination and decline in activities of daily living (ADL) were associated with posterior lateral ventricle enlargement. Decline in AD Assessment scale cognitive subscale and ADL were associated with left temporal and decline in Mini-Mental State Examination with right temporal horn enlargement. After correction for baseline hippocampal volume, decline in ADL showed a significant association with right frontal horn enlargement. Executive decline was associated with right frontal and left temporal horn enlargement.

Original languageEnglish (US)
Pages (from-to)174-181
Number of pages8
JournalAlzheimer disease and associated disorders
Issue number2
StatePublished - Apr 2013


  • AD
  • Alzheimer disease
  • MCI
  • MRI
  • brain atrophy
  • imaging
  • mild cognitive impairment
  • ventricular enlargement

ASJC Scopus subject areas

  • Clinical Psychology
  • Gerontology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health


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