Ventilator-induced lung injury: In vivo and in vitro mechanisms

Michael A. Matthay, Sunita Bhattacharya, Donald Gaver, Lorraine B. Ware, Lina H.K. Lim, Olga Syrkina, Fabien Eyal, Rolf Hubmayr

Research output: Contribution to journalReview articlepeer-review

91 Scopus citations


A lung-protective ventilator strategy significantly reduces mortality in patients with acute lung injury. Substantial progress has been made in understanding how mechanical stress can injure the lung, both in terms of alterations in barrier properties of the pulmonary endothelium and epithelium as well as in stimulating proinflammatory responses of macrophages and neutrophils.

Original languageEnglish (US)
Pages (from-to)L678-L682
JournalAmerican Journal of Physiology - Lung Cellular and Molecular Physiology
Issue number4 27-4
StatePublished - Oct 2002


  • Acute lung injury
  • Macrophages
  • Neutrophils

ASJC Scopus subject areas

  • Physiology
  • Pulmonary and Respiratory Medicine
  • Physiology (medical)
  • Cell Biology


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