Ventilator-induced lung injury: In vivo and in vitro mechanisms

Michael A. Matthay; Sunita Bhattacharya; Donald Gaver; Lorraine B. Ware; Lina H.K. Lim; Olga Syrkina; Fabien Eyal; Rolf Hubmayr

doi:10.1152/ajplung.00154.2002

Ventilator-induced lung injury: In vivo and in vitro mechanisms

Michael A. Matthay, Sunita Bhattacharya, Donald Gaver, Lorraine B. Ware, Lina H.K. Lim, Olga Syrkina, Fabien Eyal, Rolf Hubmayr

Pulmonary and Critical Care Medicine

Research output: Contribution to journal › Review article › peer-review

91 Scopus citations

Abstract

A lung-protective ventilator strategy significantly reduces mortality in patients with acute lung injury. Substantial progress has been made in understanding how mechanical stress can injure the lung, both in terms of alterations in barrier properties of the pulmonary endothelium and epithelium as well as in stimulating proinflammatory responses of macrophages and neutrophils.

Original language	English (US)
Pages (from-to)	L678-L682
Journal	American Journal of Physiology - Lung Cellular and Molecular Physiology
Volume	283
Issue number	4 27-4
DOIs	https://doi.org/10.1152/ajplung.00154.2002
State	Published - Oct 2002

Keywords

Acute lung injury
Macrophages
Neutrophils

ASJC Scopus subject areas

Physiology
Pulmonary and Respiratory Medicine
Physiology (medical)
Cell Biology

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10.1152/ajplung.00154.2002

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title = "Ventilator-induced lung injury: In vivo and in vitro mechanisms",

abstract = "A lung-protective ventilator strategy significantly reduces mortality in patients with acute lung injury. Substantial progress has been made in understanding how mechanical stress can injure the lung, both in terms of alterations in barrier properties of the pulmonary endothelium and epithelium as well as in stimulating proinflammatory responses of macrophages and neutrophils.",

keywords = "Acute lung injury, Macrophages, Neutrophils",

author = "Matthay, {Michael A.} and Sunita Bhattacharya and Donald Gaver and Ware, {Lorraine B.} and Lim, {Lina H.K.} and Olga Syrkina and Fabien Eyal and Rolf Hubmayr",

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T2 - In vivo and in vitro mechanisms

AU - Matthay, Michael A.

AU - Bhattacharya, Sunita

AU - Gaver, Donald

AU - Ware, Lorraine B.

AU - Lim, Lina H.K.

AU - Syrkina, Olga

AU - Eyal, Fabien

AU - Hubmayr, Rolf

PY - 2002/10

Y1 - 2002/10

N2 - A lung-protective ventilator strategy significantly reduces mortality in patients with acute lung injury. Substantial progress has been made in understanding how mechanical stress can injure the lung, both in terms of alterations in barrier properties of the pulmonary endothelium and epithelium as well as in stimulating proinflammatory responses of macrophages and neutrophils.

AB - A lung-protective ventilator strategy significantly reduces mortality in patients with acute lung injury. Substantial progress has been made in understanding how mechanical stress can injure the lung, both in terms of alterations in barrier properties of the pulmonary endothelium and epithelium as well as in stimulating proinflammatory responses of macrophages and neutrophils.

KW - Acute lung injury

KW - Macrophages

KW - Neutrophils

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U2 - 10.1152/ajplung.00154.2002

DO - 10.1152/ajplung.00154.2002

M3 - Review article

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JO - American Journal of Physiology - Lung Cellular and Molecular Physiology

JF - American Journal of Physiology - Lung Cellular and Molecular Physiology

IS - 4 27-4

ER -

Ventilator-induced lung injury: In vivo and in vitro mechanisms

Abstract

Keywords

ASJC Scopus subject areas

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