VEGF-Promoted surgical angiogenesis in necrotic bone

Osami Suzuki, Allen T. Bishop, Toru Sunagawa, Kosuke Katsube, Patricia F. Friedrich

Research output: Contribution to journalArticlepeer-review

35 Scopus citations


The ability of vascular endothelial growth factor (VEGF) to accelerate neoangiogenesis from implanted arterovenous (AV) bundles in necrotic bone was evaluated. A saphenous AV bundle was placed in a necrotic segment of rabbit ilium. In group II, VEGF (100 ng/h × 3 days) was administered by continuous infusion. Bone blood flow was measured with radioactive-labeled microspheres, and capillary density was determined by microangiography combined with Spälteholtz bone clearing at 1, 2, and 4 weeks. Neovascularization was observed along the implanted vascular bundle in both groups. One week after surgery, bone blood flow and vessel area were significantly higher in VEGF-treated animals (P < 0.05). No significant difference was observed at later times. Direct VEGF administration increased surgical angiogenesis and improved blood flow and neovascularization in necrotic bone 1 week after AV bundle implantation. Thereafter, a robust angiogenic response from the AV bundle was seen in both groups.

Original languageEnglish (US)
Pages (from-to)85-91
Number of pages7
Issue number1
StatePublished - 2004

ASJC Scopus subject areas

  • Surgery


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