Utilization and Cost Analysis of Lung Transplantation and Survival after 10 Years of Adapting the Lung Allocation Score

Cesar A. Keller, Thomas A. Gonwa, Launia J. White, March E. Rucci, Sue L. Visscher, Cassie C. Kennedy, Richard C. Daly, James M. Naessens

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Background. Lungs are allocated in the United States using the lung allocation score (LAS). We investigated the effect of LAS trends on lung transplant-related costs, healthcare utilization, and mortality. Methods. Utilization data from Mayo Clinic (Florida and Minnesota) from 2005 to 2015 were obtained from the electronic health records (N = 465). Costs were categorized as 1-year posttransplant or transplant episode and standardized using 2015 Medicare reimbursement and cost-to-charge ratios. Regression analysis was used to assess the relationship of LAS to length of stay (LOS), mortality, and cost of transplant. Results. The mean LAS at transplant increased from 45.7 to 58.3 during the study period, whereas the 1-year survival improved from 88.1% to 92.5% (P < 0.0001). The proportion of patients transplanted with LAS of 60 or greater increased from 16.9% to 33.3%. Posttransplant, overall, and intensive care unit LOS increased with increasing LAS. Patients with higher LAS had substantially higher transplant episode costs. An increase of LAS at transplant by 10 points increased inflation-adjusted costs by 12.0% (95% confidence interval, 9.3%-14.5%). Conclusions. The mean LAS at transplant has significantly increased over time associated with increases in LOS, resource utilization and cost. Lung allocation score has not jeopardized overall survival, but a high LAS (>60) at transplant is associated with increased mortality.

Original languageEnglish (US)
Pages (from-to)638-646
Number of pages9
Issue number3
StatePublished - Mar 1 2019

ASJC Scopus subject areas

  • Transplantation


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