Urticaria and angioedema from cyclooxygenase-2 inhibitors

P. S. Kelkar, J. H. Butterfield, H. G. Teaford

Research output: Contribution to journalArticlepeer-review

31 Scopus citations


Cyclooxygenase-2 (COX-2) inhibitors celecoxib and rofecoxib have generally been well tolerated. It has been unclear if specific COX-2 inhibitors would cross react with acetylsalicylic acid and typical nonsteroidal antiinflammatory drugs to cause urticaria or angioedema. There are no reports in the literature of hives or angioedema resulting from their use. We describe 3 patients who developed urticaria and/or angioedema from COX-2 inhibitors. With the increasing use of COX-2 inhibitors, one needs to be aware of these side effects and of possible cross reactivity between celecoxib and rofecoxib.

Original languageEnglish (US)
Pages (from-to)2553-2554
Number of pages2
JournalJournal of Rheumatology
Issue number11
StatePublished - Nov 15 2001


  • Angioedema
  • Cyclooxygenase-2 inhibitors
  • Urticaria

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology


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