Update on Obesity and Obesity Paradox in Heart Failure

Carl J. Lavie, Abhishek Sharma, Martin A. Alpert, Alban De Schutter, Francisco Lopez-Jimenez, Richard V. Milani, Hector O. Ventura

Research output: Contribution to journalReview articlepeer-review

126 Scopus citations


Obesity has reached epidemic proportions in most of the Westernized world. Overweightness and obesity adversely impact cardiac structure and function, including on both the right and, especially, left sides of the heart, with adverse affects on systolic and, especially, diastolic ventricular function. Therefore, it is not surprising that obesity markedly increases the prevalence of heart failure (HF). Nevertheless, many studies have documented an obesity paradox in large cohorts with HF, where overweight and obese have a better prognosis, at least in the short-term, compared with lean HF patients. Although weight loss clearly improves cardiac structure and function and reduces symptoms in HF, there are no large studies on the impact of weight loss on clinical events in HF, preventing definitive guidelines on optimal body composition in patients with HF.

Original languageEnglish (US)
Pages (from-to)393-400
Number of pages8
JournalProgress in Cardiovascular Diseases
Issue number4
StatePublished - Jan 1 2016


  • Fitness
  • Heart failure
  • Obesity

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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