Unexpected BP Sensitivity to Angiotensin II in a Patient With Coronavirus Disease 2019, ARDS, and Septic Shock

Hanyin Wang; Subhraleena Das; Patrick M. Wieruszewski; Jamil Taji; Brian Bartlett; Nabila Azad; Arnab Chowdhury; Gururaj J. Kolar; Nitesh Jain; Mir R. Subla; Syed Anjum Khan

doi:10.1016/j.chest.2020.04.015

Unexpected BP Sensitivity to Angiotensin II in a Patient With Coronavirus Disease 2019, ARDS, and Septic Shock

Hanyin Wang
, Subhraleena Das
, Patrick M. Wieruszewski
, Jamil Taji
, Brian Bartlett
, Nabila Azad
, Arnab Chowdhury
, Gururaj J. Kolar
, Nitesh Jain
, Mir R. Subla
, Syed Anjum Khan

Cardiovascular Medicine

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

We report the case of an 88-year-old man with coronavirus disease 2019 (COVID-19) who presented with ARDS and septic shock. The patient had exquisite BP sensitivity to low-dose angiotensin II (Ang-2), allowing for rapid liberation from high-dose vasopressors. We hypothesize that sensitivity to Ang-2 might be related to biological effect of severe acute respiratory syndrome coronavirus 2 infection. The case is suggestive of a potential role for synthetic Ang-2 for patients with COVID-19 and septic shock. Further studies are needed to confirm our observed clinical efficacy.

Original language	English (US)
Pages (from-to)	e55-e58
Journal	Chest
Volume	158
Issue number	2
DOIs	https://doi.org/10.1016/j.chest.2020.04.015
State	Published - Aug 2020

Keywords

COVID-19
SARS-CoV-2
angiotensin II
septic shock

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine
Critical Care and Intensive Care Medicine
Cardiology and Cardiovascular Medicine

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10.1016/j.chest.2020.04.015

Cite this

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title = "Unexpected BP Sensitivity to Angiotensin II in a Patient With Coronavirus Disease 2019, ARDS, and Septic Shock",

abstract = "We report the case of an 88-year-old man with coronavirus disease 2019 (COVID-19) who presented with ARDS and septic shock. The patient had exquisite BP sensitivity to low-dose angiotensin II (Ang-2), allowing for rapid liberation from high-dose vasopressors. We hypothesize that sensitivity to Ang-2 might be related to biological effect of severe acute respiratory syndrome coronavirus 2 infection. The case is suggestive of a potential role for synthetic Ang-2 for patients with COVID-19 and septic shock. Further studies are needed to confirm our observed clinical efficacy.",

keywords = "COVID-19, SARS-CoV-2, angiotensin II, septic shock",

author = "Hanyin Wang and Subhraleena Das and Wieruszewski, \{Patrick M.\} and Jamil Taji and Brian Bartlett and Nabila Azad and Arnab Chowdhury and Kolar, \{Gururaj J.\} and Nitesh Jain and Subla, \{Mir R.\} and Khan, \{Syed Anjum\}",

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year = "2020",

month = aug,

doi = "10.1016/j.chest.2020.04.015",

language = "English (US)",

volume = "158",

pages = "e55--e58",

journal = "Chest",

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TY - JOUR

T1 - Unexpected BP Sensitivity to Angiotensin II in a Patient With Coronavirus Disease 2019, ARDS, and Septic Shock

AU - Wang, Hanyin

AU - Das, Subhraleena

AU - Wieruszewski, Patrick M.

AU - Taji, Jamil

AU - Bartlett, Brian

AU - Azad, Nabila

AU - Chowdhury, Arnab

AU - Kolar, Gururaj J.

AU - Jain, Nitesh

AU - Subla, Mir R.

AU - Khan, Syed Anjum

PY - 2020/8

Y1 - 2020/8

N2 - We report the case of an 88-year-old man with coronavirus disease 2019 (COVID-19) who presented with ARDS and septic shock. The patient had exquisite BP sensitivity to low-dose angiotensin II (Ang-2), allowing for rapid liberation from high-dose vasopressors. We hypothesize that sensitivity to Ang-2 might be related to biological effect of severe acute respiratory syndrome coronavirus 2 infection. The case is suggestive of a potential role for synthetic Ang-2 for patients with COVID-19 and septic shock. Further studies are needed to confirm our observed clinical efficacy.

AB - We report the case of an 88-year-old man with coronavirus disease 2019 (COVID-19) who presented with ARDS and septic shock. The patient had exquisite BP sensitivity to low-dose angiotensin II (Ang-2), allowing for rapid liberation from high-dose vasopressors. We hypothesize that sensitivity to Ang-2 might be related to biological effect of severe acute respiratory syndrome coronavirus 2 infection. The case is suggestive of a potential role for synthetic Ang-2 for patients with COVID-19 and septic shock. Further studies are needed to confirm our observed clinical efficacy.

KW - COVID-19

KW - SARS-CoV-2

KW - angiotensin II

KW - septic shock

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DO - 10.1016/j.chest.2020.04.015

M3 - Article

C2 - 32335068

AN - SCOPUS:85088367834

SN - 0012-3692

VL - 158

SP - e55-e58

JO - Chest

JF - Chest

IS - 2

ER -

Unexpected BP Sensitivity to Angiotensin II in a Patient With Coronavirus Disease 2019, ARDS, and Septic Shock

Abstract

Keywords

ASJC Scopus subject areas

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