TY - JOUR
T1 - Understanding T cell aging to improve anti-viral immunity
AU - Zhang, Huimin
AU - Weyand, Cornelia M.
AU - Goronzy, Jörg J.
AU - Gustafson, Claire E.
N1 - Funding Information:
This work was supported by the National Institutes of Health ( R01 AI108906 to CMW, R01 AI108891 , R01 AG045779 , U19 AI057266 , R01 AI129191 to JJG, and K01 AG068373 to CEG) and with resources and the use of facilities at the Palo Alto Veterans Administration Healthcare System. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
Publisher Copyright:
© 2021 Elsevier B.V.
PY - 2021/12
Y1 - 2021/12
N2 - T cells are a critical component of the immune system and required for protection against viral and bacterial infections. However, the capacity of these cells to provide sufficient protection declines with age, leading to an increased susceptibility to and mortality from infection in older individuals. In many cases, it also contributes to poor vaccine-induced immunity. Understanding the basic biology behind T cell aging is key to unraveling these defects and, in turn, designing more effective vaccines and therapeutics for the older population. Here, we will discuss recent studies that have provided significant insight into the features of T cell aging, how these features may contribute to poor immune responses with advancing age and newer avenues of research that may further enhance anti-viral immunity in older individuals.
AB - T cells are a critical component of the immune system and required for protection against viral and bacterial infections. However, the capacity of these cells to provide sufficient protection declines with age, leading to an increased susceptibility to and mortality from infection in older individuals. In many cases, it also contributes to poor vaccine-induced immunity. Understanding the basic biology behind T cell aging is key to unraveling these defects and, in turn, designing more effective vaccines and therapeutics for the older population. Here, we will discuss recent studies that have provided significant insight into the features of T cell aging, how these features may contribute to poor immune responses with advancing age and newer avenues of research that may further enhance anti-viral immunity in older individuals.
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U2 - 10.1016/j.coviro.2021.09.017
DO - 10.1016/j.coviro.2021.09.017
M3 - Review article
C2 - 34688983
AN - SCOPUS:85120671801
SN - 1879-6257
VL - 51
SP - 127
EP - 133
JO - Current Opinion in Virology
JF - Current Opinion in Virology
ER -