Two-dimensional chemical exchange and cross-relaxation spectroscopy of coupled nuclear spins

S. Macura; Y. Huang; D. Suter; R. R. Ernst

doi:10.1016/0022-2364(81)90037-8

Two-dimensional chemical exchange and cross-relaxation spectroscopy of coupled nuclear spins

S. Macura
, Y. Huang
, D. Suter
, R. R. Ernst

Biochemistry and Molecular Biology

Research output: Contribution to journal › Article › peer-review

931 Scopus citations

Abstract

The features of two-dimensional cross-relaxation and chemical exchange spectroscopy of coupled spins are investigated theoretically and by experiment. It is shown that spin-spin couplings can lead to J cross-peaks in analogy to cross-peaks in two-dimensional autocorrelated spectroscopy. They reflect a coherent magnetization transfer in contrast to the incoherent processes responsible for cross-relaxation and for chemical exchange. Possibilities of selectively suppressing J cross-peaks are discussed.

Original language	English (US)
Pages (from-to)	259-281
Number of pages	23
Journal	Journal of Magnetic Resonance (1969)
Volume	43
Issue number	2
DOIs	https://doi.org/10.1016/0022-2364(81)90037-8
State	Published - May 1981

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10.1016/0022-2364(81)90037-8

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title = "Two-dimensional chemical exchange and cross-relaxation spectroscopy of coupled nuclear spins",

abstract = "The features of two-dimensional cross-relaxation and chemical exchange spectroscopy of coupled spins are investigated theoretically and by experiment. It is shown that spin-spin couplings can lead to J cross-peaks in analogy to cross-peaks in two-dimensional autocorrelated spectroscopy. They reflect a coherent magnetization transfer in contrast to the incoherent processes responsible for cross-relaxation and for chemical exchange. Possibilities of selectively suppressing J cross-peaks are discussed.",

author = "S. Macura and Y. Huang and D. Suter and Ernst, \{R. R.\}",

note = "Funding Information: Partial support by the Swiss National Science Foundation and by a postdoctoral fellowship by the Research Fund of S. R. Serbia, Yugoslavia, to S.M. is acknowledged. The authors would like to thank Mr. M. Linder for extensive help and advice with regard to computer software. Some preliminary unpublished calculations of J coupling effects in 2D exchange spectroscopy have been performed by Dr. A. Wokaun. The authors are also indebted to Dr. Anil Kumar and Professor K. Wtlthrich for several stimulating discussions. The manuscript was typed by Miss I. Milller.",

year = "1981",

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doi = "10.1016/0022-2364(81)90037-8",

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T1 - Two-dimensional chemical exchange and cross-relaxation spectroscopy of coupled nuclear spins

AU - Macura, S.

AU - Huang, Y.

AU - Suter, D.

AU - Ernst, R. R.

N1 - Funding Information: Partial support by the Swiss National Science Foundation and by a postdoctoral fellowship by the Research Fund of S. R. Serbia, Yugoslavia, to S.M. is acknowledged. The authors would like to thank Mr. M. Linder for extensive help and advice with regard to computer software. Some preliminary unpublished calculations of J coupling effects in 2D exchange spectroscopy have been performed by Dr. A. Wokaun. The authors are also indebted to Dr. Anil Kumar and Professor K. Wtlthrich for several stimulating discussions. The manuscript was typed by Miss I. Milller.

PY - 1981/5

Y1 - 1981/5

N2 - The features of two-dimensional cross-relaxation and chemical exchange spectroscopy of coupled spins are investigated theoretically and by experiment. It is shown that spin-spin couplings can lead to J cross-peaks in analogy to cross-peaks in two-dimensional autocorrelated spectroscopy. They reflect a coherent magnetization transfer in contrast to the incoherent processes responsible for cross-relaxation and for chemical exchange. Possibilities of selectively suppressing J cross-peaks are discussed.

AB - The features of two-dimensional cross-relaxation and chemical exchange spectroscopy of coupled spins are investigated theoretically and by experiment. It is shown that spin-spin couplings can lead to J cross-peaks in analogy to cross-peaks in two-dimensional autocorrelated spectroscopy. They reflect a coherent magnetization transfer in contrast to the incoherent processes responsible for cross-relaxation and for chemical exchange. Possibilities of selectively suppressing J cross-peaks are discussed.

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DO - 10.1016/0022-2364(81)90037-8

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AN - SCOPUS:49049150378

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VL - 43

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EP - 281

JO - Journal of Magnetic Resonance (1969)

JF - Journal of Magnetic Resonance (1969)

IS - 2

ER -

Two-dimensional chemical exchange and cross-relaxation spectroscopy of coupled nuclear spins

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