Tumor selective uptake of drug-nanodiamond complexes improves therapeutic outcome in pancreatic cancer

Vijay S. Madamsetty; Anil Sharma; Maria Toma; Stefanie Samaniego; Audrey Gallud; Enfeng Wang; Krishnendu Pal; Debabrata Mukhopadhyay; Bengt Fadeel

doi:10.1016/j.nano.2019.02.020

Tumor selective uptake of drug-nanodiamond complexes improves therapeutic outcome in pancreatic cancer

Vijay S. Madamsetty
, Anil Sharma
, Maria Toma
, Stefanie Samaniego
, Audrey Gallud
, Enfeng Wang
, Krishnendu Pal
, Debabrata Mukhopadhyay
, Bengt Fadeel

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is one of the leading causes of cancer-related deaths and novel treatment approaches are urgently needed. Here we show that poly(ethylene glycol)-functionalized nanodiamonds loaded with doxorubicin (ND-PEG-DOX) afforded a considerable improvement over free drug in an orthotopic pancreatic xenograft model. ND-PEG-DOX complexes were also superior to free DOX in 3-dimensional (3D) tumor spheroids of PDAC. ND-PEG showed no cytotoxicity towards macrophages, and histopathological analysis showed no abnormalities of major organs upon in vivo administration of ND-PEG-DOX. These results provide evidence that ND-mediated drug delivery may serve as a means of improving the therapeutic outcome in PDAC.

Original language	English (US)
Pages (from-to)	112-121
Number of pages	10
Journal	Nanomedicine: Nanotechnology, Biology, and Medicine
Volume	18
DOIs	https://doi.org/10.1016/j.nano.2019.02.020
State	Published - Jun 2019

Keywords

Drug delivery
Nanodiamonds
Nanomedicine
Pancreatic adenocarcinoma

ASJC Scopus subject areas

Bioengineering
Medicine (miscellaneous)
Molecular Medicine
Biomedical Engineering
General Materials Science
Pharmaceutical Science

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10.1016/j.nano.2019.02.020

Cite this

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title = "Tumor selective uptake of drug-nanodiamond complexes improves therapeutic outcome in pancreatic cancer",

abstract = "Pancreatic ductal adenocarcinoma (PDAC) is one of the leading causes of cancer-related deaths and novel treatment approaches are urgently needed. Here we show that poly(ethylene glycol)-functionalized nanodiamonds loaded with doxorubicin (ND-PEG-DOX) afforded a considerable improvement over free drug in an orthotopic pancreatic xenograft model. ND-PEG-DOX complexes were also superior to free DOX in 3-dimensional (3D) tumor spheroids of PDAC. ND-PEG showed no cytotoxicity towards macrophages, and histopathological analysis showed no abnormalities of major organs upon in vivo administration of ND-PEG-DOX. These results provide evidence that ND-mediated drug delivery may serve as a means of improving the therapeutic outcome in PDAC.",

keywords = "Drug delivery, Nanodiamonds, Nanomedicine, Pancreatic adenocarcinoma",

author = "Madamsetty, \{Vijay S.\} and Anil Sharma and Maria Toma and Stefanie Samaniego and Audrey Gallud and Enfeng Wang and Krishnendu Pal and Debabrata Mukhopadhyay and Bengt Fadeel",

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year = "2019",

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doi = "10.1016/j.nano.2019.02.020",

language = "English (US)",

volume = "18",

pages = "112--121",

journal = "Nanomedicine: Nanotechnology, Biology, and Medicine",

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}

TY - JOUR

T1 - Tumor selective uptake of drug-nanodiamond complexes improves therapeutic outcome in pancreatic cancer

AU - Madamsetty, Vijay S.

AU - Sharma, Anil

AU - Toma, Maria

AU - Samaniego, Stefanie

AU - Gallud, Audrey

AU - Wang, Enfeng

AU - Pal, Krishnendu

AU - Mukhopadhyay, Debabrata

AU - Fadeel, Bengt

PY - 2019/6

Y1 - 2019/6

N2 - Pancreatic ductal adenocarcinoma (PDAC) is one of the leading causes of cancer-related deaths and novel treatment approaches are urgently needed. Here we show that poly(ethylene glycol)-functionalized nanodiamonds loaded with doxorubicin (ND-PEG-DOX) afforded a considerable improvement over free drug in an orthotopic pancreatic xenograft model. ND-PEG-DOX complexes were also superior to free DOX in 3-dimensional (3D) tumor spheroids of PDAC. ND-PEG showed no cytotoxicity towards macrophages, and histopathological analysis showed no abnormalities of major organs upon in vivo administration of ND-PEG-DOX. These results provide evidence that ND-mediated drug delivery may serve as a means of improving the therapeutic outcome in PDAC.

AB - Pancreatic ductal adenocarcinoma (PDAC) is one of the leading causes of cancer-related deaths and novel treatment approaches are urgently needed. Here we show that poly(ethylene glycol)-functionalized nanodiamonds loaded with doxorubicin (ND-PEG-DOX) afforded a considerable improvement over free drug in an orthotopic pancreatic xenograft model. ND-PEG-DOX complexes were also superior to free DOX in 3-dimensional (3D) tumor spheroids of PDAC. ND-PEG showed no cytotoxicity towards macrophages, and histopathological analysis showed no abnormalities of major organs upon in vivo administration of ND-PEG-DOX. These results provide evidence that ND-mediated drug delivery may serve as a means of improving the therapeutic outcome in PDAC.

KW - Drug delivery

KW - Nanodiamonds

KW - Nanomedicine

KW - Pancreatic adenocarcinoma

UR - https://www.scopus.com/pages/publications/85063594526

UR - https://www.scopus.com/pages/publications/85063594526#tab=citedBy

U2 - 10.1016/j.nano.2019.02.020

DO - 10.1016/j.nano.2019.02.020

M3 - Article

C2 - 30849547

AN - SCOPUS:85063594526

SN - 1549-9634

VL - 18

SP - 112

EP - 121

JO - Nanomedicine: Nanotechnology, Biology, and Medicine

JF - Nanomedicine: Nanotechnology, Biology, and Medicine

ER -

Tumor selective uptake of drug-nanodiamond complexes improves therapeutic outcome in pancreatic cancer

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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