@article{863e69678d6c47f7ac3daaf7a4e1b30f,
title = "Treatment of unfavorable myelodysplastic syndrome with all-trans-retinoic acid and subcutaneous Ara C",
abstract = "Thirty patients with high-risk myelodysplastic syndrome, defined as>5% bone marrow blasts, were treated with a combination of oral all-trans-retinoic acid (45 mg/m2 daily) and subcutaneous AraC (10 mg/m2) on days 1-14 of each 28-35 day cycle repeated for 2-6 cycles. Complete remission lasting 9, 12, and 15 months was achieved in three patients. Partial and minor response did not translate into meaningful clinical improvement, like complete responders. Overall incidence of leukemia transformation and survival of this cohort of patients was no different from the expected outcome for a group of patients with similar characteristics. Copyright (C) 1999 Elsevier Science Ltd.",
keywords = "Chemotherapy, Leukemia, Myelodysplastic syndrome, Treatment",
author = "Louis Letendre and Pierre Noel and White, {William L.} and Ayalew Tefferi and Litzow, {Mark R.} and Li, {Chin Yang} and Georgene Schroeder",
note = "Funding Information: Supported by Research Grant #CA69912-64 from the National Institutes of Health. L. Letendre provided the concept, design, drafting of article, critical revision, final approval, provided study patients and adminstrative support. P. Noel was a co-prinicpal investigator and contributed to the design, analysis of data, provided patients for the study, gave final approval to the paper and assisted with obtaining funds. A. Tefferi and M. Litzow provided patients, helped with the analysis of data, drafting and revision of the paper and gave final approval. CY Li confirmed the diagnosis, assisted with data interpretation and gave final approval. W. White provided critical revision, gave final approval and provided patients for the study. G. Schroeder provided statistical and logistical support, helped to assemble and interpret the data and gave final approval. ",
year = "1999",
month = sep,
doi = "10.1016/S0145-2126(99)00095-8",
language = "English (US)",
volume = "23",
pages = "811--815",
journal = "Leukemia Research",
issn = "0145-2126",
publisher = "Elsevier Limited",
number = "9",
}