Treatment of restless legs syndrome with gabapentin

Research output: Contribution to journalArticlepeer-review

104 Scopus citations


Gabapentin is a well tolerated anticonvulsant, structurally related to γ-aminobutyric acid, with an unknown mechanism of action. Restless legs syndrome (RLS) is a disorder characterized by sensory and motor symptoms in the legs that is best treated with dopaminergic drugs and opiates. In this open-label study, eight patients with RLS were treated with gabapentin. Four of the eight had a beneficial response, three with almost complete resolution of symptoms for up to 6 months. For a disorder that is often difficult to treat, these results are encouraging, and they suggest that a placebo- controlled trial is warranted.

Original languageEnglish (US)
Pages (from-to)148-151
Number of pages4
JournalClinical Neuropharmacology
Issue number2
StatePublished - Jan 1 1997


  • Gabapentin
  • Movement disorders
  • Restless legs syndrome

ASJC Scopus subject areas

  • Pharmacology
  • Clinical Neurology
  • Pharmacology (medical)


Dive into the research topics of 'Treatment of restless legs syndrome with gabapentin'. Together they form a unique fingerprint.

Cite this