Treatment of Hypereosinophilic Syndromes with Prednisone, Hydroxyurea, and Interferon

Joseph H. Butterfield

Research output: Contribution to journalReview articlepeer-review

19 Scopus citations


The hypereosinophilic syndromes continue to challenge our clinical acumen and skills. Prednisone, hydroxyurea, and interferon alpha 2b are three of the oldest agents that allow control of eosinophilia and its devastating clinical consequences. They still work. As our experience with them has grown, it has become evident that use of these agents in combination will control eosinophilia in most patients. Moreover, with time, the doses can frequently be reduced. Even with the advent of newer agents for treatment of hypereosinophilic syndromes, these three medications still afford an excellent, cost-effective avenue for disease management.

Original languageEnglish (US)
Pages (from-to)493-518
Number of pages26
JournalImmunology and Allergy Clinics of North America
Issue number3
StatePublished - Aug 1 2007

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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