Treating coronary disease and the impact of endothelial dysfunction

Yasushi Matsuzawa, Raviteja R. Guddeti, Taek Geun Kwon, Lilach O. Lerman, Amir Lerman

Research output: Contribution to journalArticlepeer-review

36 Scopus citations


Ischemic heart disease is the leading cause of morbidity and mortality throughout the world. Many clinical trials have suggested that lifestyle and pharmacologic interventions are effective in attenuating atherosclerotic disease progression and events development. However, an individualized approach with careful consideration to comprehensive vascular health is necessary to perform successful intervention strategies. Endothelial dysfunction plays a pivotal role in the early stage of atherosclerosis and is also associated with plaque progression and occurrence of atherosclerotic complications. The assessment of endothelial function provides us with important information about individual patient risk, progress and vulnerability of disease, and guidance of therapy. Thus, the application of endothelial function assessment might enable clinicians to innovate ideal individualized medicine. In this review, we summarize the current knowledge on the impact of pharmacological therapies for atherosclerotic cardiovascular disease on endothelial dysfunction, and argue for the utility of non-invasive assessment of endothelial function aiming at individualized medicine.

Original languageEnglish (US)
Pages (from-to)431-442
Number of pages12
JournalProgress in Cardiovascular Diseases
Issue number5
StatePublished - Mar 1 2015


  • Atherosclerosis
  • Cardiovascular disease
  • Endothelial function
  • Prognosis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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