Treadmill exercise increases cell proliferation in dentate gyrus of rats with streptozotocin-induced diabetes

Hyun Bae Kim, Mi Hyeon Jang, Min Chul Shin, Baek Vin Lim, Young Pyo Kim, Kyung Ji Kim, Ee Hwa Kim, Chang Ju Kim

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


Diabetes mellitus is a common and serious metabolic disorder in humans. Streptozotocin (STZ)-induced diabetic rats were shown to produce a significant reduction in the number of proliferating cells in the dentate gyrus. In the present study, the effect of treadmill exercise on cell proliferation in the dentate gyrus of rats with STZ-induced diabetes was investigated via immunohistochemistry. Male Sprague-Dawley rats were divided into four groups: the control-rest group, the control-exercise group, the diabetes-rest group, and the diabetes-exercise group. Each of the animals of the diabetes groups was given a single injection of STZ (50 mg/kg) intraperitoneally. All animals were injected with 5-bromo-2′-deoxyuridine (50 mg/kg) for six consecutive days, starting on the second day after STZ injection, and rats of the exercise groups were made to run on treadmill for 30 min each day over the same period. On the eighth day of the experiment, all animals were sacrificed. In the present results, it was shown that cell proliferation in the dentate gyrus is suppressed under diabetic conditions, and that treadmill is effective in enhancing hippocampal granular cell proliferation in rats with STZ-induced diabetes. These results raise the possibility that treadmill exercise is of help in the alleviation of the central neural sequelae of diabetes mellitus.

Original languageEnglish (US)
Pages (from-to)29-33
Number of pages5
JournalJournal of Diabetes and its Complications
Issue number1
StatePublished - Jan 2003


  • 5-Bromo-2′-deoxyuridine
  • Diabetes
  • Streptozotocin
  • Treadmill running

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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