Trastuzumab-induced cardiotoxicity: Heart failure at the crossroads

Partho P. Sengupta, Donald W. Northfelt, Federico Gentile, Jose L. Zamorano, Bijoy K. Khandheria

Research output: Contribution to journalReview articlepeer-review

60 Scopus citations


Trastuzumab, a drug targeting human epidermal growth factor receptor 2, improves survival rate in women with metastatic breast cancer. Symptomatic heart failure, a serious adverse effect of trastuzumab, occurs in 1% to 4% of patients treated with the antibody, whereas left ventricular ejection fraction declines substantially in 10% of patients. The prevalence of cardiotoxic effects of trastuzumab appears to increase with exposure to anthracyclines. Serial assessment of left ventricular function with 2-dimensional echocardiography or radionuclide ventriculography is the most practical means of monitoring cardiotoxicity. Patients who develop cardiotoxicity while receiving trastuzumab therapy generally improve once use of the agent is discontinued.

Original languageEnglish (US)
Pages (from-to)197-203
Number of pages7
JournalMayo Clinic proceedings
Issue number2
StatePublished - Feb 2008

ASJC Scopus subject areas

  • General Medicine


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