Translocation(X;Y)(p22.33;p11.2) in XX males: Etiology of male phenotype

R. E. Magenis, M. J. Webb, R. S. McKean, D. Tomar, L. J. Allen, H. Kammer, D. L. Van Dyke, E. Lovrien

Research output: Contribution to journalArticlepeer-review

38 Scopus citations


Analysis of G-banded prometaphase chromosomes from three XX males revealed extra bands on the distal end of one X short arm. These bands were similar both in size and staining properties to the distal Y short arm of their fathers (in the two cases examined) and also to other chromosomally normal males. The extra material on the abnormal X chromosomes was not C-or G-11 positive in the two cases examined, suggesting that the proximal Y long arm was not present. Previous karyotype-phenotype correlations with structurally altered Y chromosomes provided evidence for localization of male determinants on the Y short arm. The present findings in XX males provide support for more precise localization, to bands p11.2→pter of Y short arm.

Original languageEnglish (US)
Pages (from-to)271-276
Number of pages6
JournalHuman genetics
Issue number3
StatePublished - Dec 1982

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)


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