Transient activation of C-MYC protooncogene expression in leydig cells by human chorionic gonadotropin

T. Lin; J. Blaisdell; K. W. Barbour; E. A. Thompson

doi:10.1016/S0006-291X(88)80021-4

Transient activation of C-MYC protooncogene expression in leydig cells by human chorionic gonadotropin

T. Lin, J. Blaisdell, K. W. Barbour, E. A. Thompson

Cancer Biology

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Abstract

This study evaluated the effects of in vivo administration of human chorionic gonadotropin (hCG) on c-myc oncogene expression in Leydig cells. Sprague-Dawley rats (46-50 days old) were treated with hCG (10 units, i.p.), and purified Leydig cells were isolated 1-24 h later. HCG caused a transient elevation of c-myc mRNA in 4 h and returned to normal or lower than normal levels at 24 h. There was no change in c-fos or β-actin mRNA levels. Our results suggest that the growth promoting effects of hCG on Leydig cells may be mediated by the transient expression of c-myc protooncogene.

Original language	English (US)
Pages (from-to)	121-126
Number of pages	6
Journal	Biochemical and Biophysical Research Communications
Volume	157
Issue number	1
DOIs	https://doi.org/10.1016/S0006-291X(88)80021-4
State	Published - Nov 30 1988

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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10.1016/S0006-291X(88)80021-4

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title = "Transient activation of C-MYC protooncogene expression in leydig cells by human chorionic gonadotropin",

abstract = "This study evaluated the effects of in vivo administration of human chorionic gonadotropin (hCG) on c-myc oncogene expression in Leydig cells. Sprague-Dawley rats (46-50 days old) were treated with hCG (10 units, i.p.), and purified Leydig cells were isolated 1-24 h later. HCG caused a transient elevation of c-myc mRNA in 4 h and returned to normal or lower than normal levels at 24 h. There was no change in c-fos or β-actin mRNA levels. Our results suggest that the growth promoting effects of hCG on Leydig cells may be mediated by the transient expression of c-myc protooncogene.",

author = "T. Lin and J. Blaisdell and Barbour, {K. W.} and Thompson, {E. A.}",

note = "Funding Information: ACKNOWLEDGEMENT: This work was supported by V.A. Medical Research Funds. thank Margaret Lin for her technical assistance. We also thank Drs. A. M. Forsthoefel, P. R. Housley and K. Huber for their helpful advices.",

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T1 - Transient activation of C-MYC protooncogene expression in leydig cells by human chorionic gonadotropin

AU - Lin, T.

AU - Blaisdell, J.

AU - Barbour, K. W.

AU - Thompson, E. A.

N1 - Funding Information: ACKNOWLEDGEMENT: This work was supported by V.A. Medical Research Funds. thank Margaret Lin for her technical assistance. We also thank Drs. A. M. Forsthoefel, P. R. Housley and K. Huber for their helpful advices.

PY - 1988/11/30

Y1 - 1988/11/30

N2 - This study evaluated the effects of in vivo administration of human chorionic gonadotropin (hCG) on c-myc oncogene expression in Leydig cells. Sprague-Dawley rats (46-50 days old) were treated with hCG (10 units, i.p.), and purified Leydig cells were isolated 1-24 h later. HCG caused a transient elevation of c-myc mRNA in 4 h and returned to normal or lower than normal levels at 24 h. There was no change in c-fos or β-actin mRNA levels. Our results suggest that the growth promoting effects of hCG on Leydig cells may be mediated by the transient expression of c-myc protooncogene.

AB - This study evaluated the effects of in vivo administration of human chorionic gonadotropin (hCG) on c-myc oncogene expression in Leydig cells. Sprague-Dawley rats (46-50 days old) were treated with hCG (10 units, i.p.), and purified Leydig cells were isolated 1-24 h later. HCG caused a transient elevation of c-myc mRNA in 4 h and returned to normal or lower than normal levels at 24 h. There was no change in c-fos or β-actin mRNA levels. Our results suggest that the growth promoting effects of hCG on Leydig cells may be mediated by the transient expression of c-myc protooncogene.

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Transient activation of C-MYC protooncogene expression in leydig cells by human chorionic gonadotropin

Abstract

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