Transgenic Animal Models of Proteinopathies

Naruhiko Sahara, Heather Melrose, Simon D'alton, Jada Lewis

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations


Proteinopathies are a family of neurodegenerative disorders that are neuropathologically characterized by the abnormal intracellular and/or extracellular aggregation of one or more proteins. These diseases can be further subdivided based on the specific protein aggregates formed. In this chapter, we focus on the mouse lines that have been generated to model four major families of proteinopathies termed the tauopathies, amyloidosis, synucleinopathies, and TDP-43 proteinopathies.

Original languageEnglish (US)
Title of host publicationNeurodegeneration
Subtitle of host publicationThe Molecular Pathology of Dementia and Movement Disorders: Second Edition
Number of pages11
ISBN (Print)9781405196932
StatePublished - Sep 21 2011


  • Alzheimer's disease
  • Amyloidosis
  • Amyotrophic lateral sclerosis
  • Frontotemporal dementia
  • Neurodegenerative disorders
  • Parkinson's disease
  • Protein aggregates
  • Synucleinopathies
  • TDP-43 proteinopathies
  • Tauopathies

ASJC Scopus subject areas

  • General Medicine


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