Towards a classification of biomarkers of neuropsychiatric disease: From encompass to compass

J. Davis, M. Maes, A. Andreazza, J. J. McGrath, S. J. Tye, M. Berk

Research output: Contribution to journalReview articlepeer-review

72 Scopus citations


There is currently considerable imprecision in the nosology of biomarkers used in the study of neuropsychiatric disease. The neuropsychiatric field lags behind others such as oncology, wherein, rather than using 'biomarker' as a blanket term for a diverse range of clinical phenomena, biomarkers have been actively classified into separate categories, including prognostic and predictive tests. A similar taxonomy is proposed for neuropsychiatric diseases in which the core biology remains relatively unknown. This paper divides potential biomarkers into those of (1) risk, (2) diagnosis/trait, (3) state or acuity, (4) stage, (5) treatment response and (6) prognosis, and provides illustrative exemplars. Of course, biomarkers rely on available technology and, as we learn more about the neurobiological correlates of neuropsychiatric disorders, we will realize that the classification of biomarkers across these six categories can change, and some markers may fit into more than one category.

Original languageEnglish (US)
Pages (from-to)152-153
Number of pages2
JournalMolecular Psychiatry
Issue number2
StatePublished - Feb 1 2015

ASJC Scopus subject areas

  • Molecular Biology
  • Cellular and Molecular Neuroscience
  • Psychiatry and Mental health


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